The Effect of Ketogenic-caloric Restricted Diet on Metabolic Endotoxemia in Prediabetic Obese Adults

NANot yet recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

April 5, 2025

Primary Completion Date

July 31, 2025

Study Completion Date

November 30, 2025

Conditions
Insulin ResistanceMetabolic EndotoxemiaInflammation BiomarkersKetogenic DietCaloric RestrictionObesityPrediabetes
Interventions
OTHER

Ketogenic diet with caloric restriction

Participants in this group will follow a ketogenic diet with caloric restriction (-550 kcal/day), consisting of approximately 5-10% carbohydrates, 15-25% protein, 70-80% fat. The daily carbohydrate intake will be limited to less than 50g per day. The intervention will last for 12 weeks, with regular dietary monitoring and adherence checks every two weeks.

OTHER

Normal diet with caloric restriction

Participants in this group will follow a normal diet with caloric restriction (-550 kcal/day), consisting of approximately 45-60% carbohydrates, 15-25% protein, 20-30% fat. The intervention will last for 12 weeks, with regular dietary monitoring and adherence checks every two weeks.

OTHER

Normal diet without caloric restriction

Participants in this group will follow a normal diet without caloric restriction, consisting of approximately 45-60% carbohydrates, 15-25% protein, 20-30% fat. The intervention will last for 12 weeks, with regular dietary monitoring and adherence checks every two weeks.

Trial Locations (1)

Unknown

Aseel nutrition center, Amman

All Listed Sponsors
lead

University of Jordan

OTHER