A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma (GOLSEEK-4)

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

July 28, 2025

Primary Completion Date

April 24, 2028

Study Completion Date

July 31, 2030

Conditions
Follicular Lymphoma
Interventions
DRUG

Golcadomide

Specified dose on specified days

DRUG

Rituximab

Specified dose on specified days

DRUG

Lenalidomide

Specified dose on specified days

DRUG

Cyclophosphamide

Specified dose on specified days

DRUG

Doxorubicin

Specified dose on specified days

DRUG

Vincristine

Specified dose on specified days

DRUG

Prednisone/Prednisolone

Specified dose on specified days

DRUG

Bendamustine

Specified dose on specified days

Trial Locations (160)

2145

RECRUITING

Westmead Hospital, Westmead

3084

NOT_YET_RECRUITING

Local Institution - 0128, Heidelberg

3144

RECRUITING

Cabrini Hospital - Malvern, Malvern

5042

NOT_YET_RECRUITING

Local Institution - 0132, Adelaide

6000

NOT_YET_RECRUITING

Local Institution - 0127, Perth

WITHDRAWN

Local Institution - 0224, Perth

7000

NOT_YET_RECRUITING

Local Institution - 0131, Hobart

10126

NOT_YET_RECRUITING

Local Institution - 0157, Torino

11001

NOT_YET_RECRUITING

Local Institution - 0251, Abu Dhabi

11426

NOT_YET_RECRUITING

Local Institution - 0054, Riyadh

11526

RECRUITING

"General Hospital of Athens Laiko", Αthens

12713

NOT_YET_RECRUITING

Local Institution - 0052, Riyadh

15121

NOT_YET_RECRUITING

Local Institution - 0102, Alessandria

18012

RECRUITING

Hospital Universitario Virgen Nieves, Granada

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20521

NOT_YET_RECRUITING

Local Institution - 0152, Turku

21201

NOT_YET_RECRUITING

Local Institution - 0023, Baltimore

21204

RECRUITING

Greater Baltimore Medical Center, Towson

22304

NOT_YET_RECRUITING

Local Institution - 0238, Fairfax

22408

RECRUITING

Hematology Oncology Associates of Fredericksburg, Fredericksburg

24014

RECRUITING

Blue Ridge Cancer Care, Roanoke

28031

RECRUITING

Hospital Universitario Infanta Leonor, Madrid

28040

NOT_YET_RECRUITING

Local Institution - 0123, Madrid

30060

RECRUITING

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta

30265

RECRUITING

Southeastern Regional Medical Center, Newnan

31100

RECRUITING

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse

31444

NOT_YET_RECRUITING

Local Institution - 0099, Dammam

32256

NOT_YET_RECRUITING

Local Institution - 0008, Jacksonville

33343

NOT_YET_RECRUITING

Local Institution - 0223, Mersin

33600

RECRUITING

CHU Bordeaux Haut-Leveque, Pessac

33606

NOT_YET_RECRUITING

Local Institution - 0214, Tampa

33612

NOT_YET_RECRUITING

Local Institution - 0217, Tampa

34098

NOT_YET_RECRUITING

Local Institution - 0195, Istanbul- Fatih

34295

RECRUITING

Chu Saint Eloi, Montpellier

35205

NOT_YET_RECRUITING

Local Institution - 0225, Birmingham

36607

RECRUITING

Infirmary Cancer Care, Mobile

37075

NOT_YET_RECRUITING

Local Institution - 0220, Göttingen

39008

RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

40138

NOT_YET_RECRUITING

Local Institution - 0104, Bologna

40225

NOT_YET_RECRUITING

Local Institution - 0193, Düsseldorf

40536

NOT_YET_RECRUITING

Local Institution - 0218, Lexington

44263

RECRUITING

GEFOS Gesellschaft f. onkologische Studien, Dortmund

46010

RECRUITING

Hospital Clinico de Valencia, Valencia

47014

RECRUITING

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola

48153

WITHDRAWN

Local Institution - 0231, Münster

NOT_YET_RECRUITING

Local Institution - 0232, Münster

50309

NOT_YET_RECRUITING

Local Institution - 0243, Waukee

52242

NOT_YET_RECRUITING

Local Institution - 0253, Iowa City

56126

RECRUITING

Azienda Ospedaliero Universitaria Pisana, Pisa

59037

RECRUITING

Hopital Claude Huriez - CHU de Lille, Lille

60005

NOT_YET_RECRUITING

Local Institution - 0240, Arlington Heights

66205

NOT_YET_RECRUITING

Local Institution - 0216, Westwood

66424

RECRUITING

Universitaetsklinikum des Saarlandes, Homburg

69310

NOT_YET_RECRUITING

Local Institution - 0042, Pierre-Bénite

72205

NOT_YET_RECRUITING

Local Institution - 0215, Little Rock

75010

NOT_YET_RECRUITING

Local Institution - 0191, Paris

75702

RECRUITING

Texas Oncology - Northeast Texas, Tyler

76104

NOT_YET_RECRUITING

Local Institution - 0212, Fort Worth

78240

NOT_YET_RECRUITING

Local Institution - 0230, San Antonio

78705

RECRUITING

Texas Oncology - Central/South Texas, Austin

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

81337

NOT_YET_RECRUITING

Local Institution - 0162, München

86156

RECRUITING

Klinikum Augsburg, Augsburg

89081

NOT_YET_RECRUITING

Local Institution - 0163, Ulm

90220

NOT_YET_RECRUITING

Local Institution - 0151, Oulu

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92210

NOT_YET_RECRUITING

Local Institution - 0044, Saint-Cloud

92510

NOT_YET_RECRUITING

Local Institution - 0252, Abu Dhabi

94143

RECRUITING

UCSF Helen Diller Medical Center at Parnassus Heights, San Francisco

97080

NOT_YET_RECRUITING

Local Institution - 0221, Würzburg

98684

NOT_YET_RECRUITING

Local Institution - 0143, Vancouver

99089

RECRUITING

HELIOS Klinikum Erfurt, Erfurt

99508

RECRUITING

Alaska Oncology and Hematology, Anchorage

100038

NOT_YET_RECRUITING

Local Institution - 0246, Beijing

100142

RECRUITING

Beijing Cancer hospital, Beijing

110004

NOT_YET_RECRUITING

Local Institution - 0179, Shenyang

110029

NOT_YET_RECRUITING

Local Institution - 0142, New Delhi

110042

NOT_YET_RECRUITING

Local Institution - 0242, Shenyang

130000

NOT_YET_RECRUITING

Local Institution - 0239, Changchun

130021

NOT_YET_RECRUITING

Local Institution - 0177, Changchun

150081

NOT_YET_RECRUITING

Local Institution - 0241, Harbin

200032

NOT_YET_RECRUITING

Local Institution - 0181, Shanghai

200065

NOT_YET_RECRUITING

Local Institution - 0249, Shanghai

215006

NOT_YET_RECRUITING

Local Institution - 0233, Suzhou

250117

RECRUITING

Shandong Cancer Hospital, Jinan

300060

NOT_YET_RECRUITING

Local Institution - 0182, Tianjin

300121

RECRUITING

Tianjin People' s Hospital, Tianjin

310022

NOT_YET_RECRUITING

Local Institution - 0184, Hangzhou

330006

NOT_YET_RECRUITING

Local Institution - 0178, Nanchang

350001

NOT_YET_RECRUITING

Local Institution - 0172, Fuzhou Fujian

410008

NOT_YET_RECRUITING

Local Institution - 0175, Changsha

430022

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

450008

NOT_YET_RECRUITING

Local Institution - 0174, Zhengzhou

500033

NOT_YET_RECRUITING

Local Institution - 0140, Hyderabad

500082

NOT_YET_RECRUITING

Local Institution - 0138, Hyderabad

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

560099

NOT_YET_RECRUITING

Local Institution - 0139, Bengaluru

646000

NOT_YET_RECRUITING

Local Institution - 0234, Sichuan

650118

NOT_YET_RECRUITING

Local Institution - 0248, Kunming

7580206

NOT_YET_RECRUITING

Local Institution - 0154, Santiago

8320325

NOT_YET_RECRUITING

Local Institution - 0155, Santiago

8420383

NOT_YET_RECRUITING

Local Institution - 0153, Santiago

02114

NOT_YET_RECRUITING

Local Institution - 0145, Boston

02215

NOT_YET_RECRUITING

Local Institution - 0244, Boston

NOT_YET_RECRUITING

Local Institution - 0247, Boston

39401-7233

RECRUITING

Hattiesburg Clinic Hematology/Oncology, Hattiesburg

02903

NOT_YET_RECRUITING

Local Institution - 0144, Providence

29041-295

NOT_YET_RECRUITING

Local Institution - 0159, Vitória

24220-070

NOT_YET_RECRUITING

Local Institution - 0088, Niterói

90110-270

NOT_YET_RECRUITING

Local Institution - 0087, Porto Alegre

04543-000

NOT_YET_RECRUITING

Local Institution - 0079, São Paulo

22250-905

NOT_YET_RECRUITING

Local Institution - 0089, Rio de Janeiro

01246-000

NOT_YET_RECRUITING

Local Institution - 0066, São Paulo

05652-900

NOT_YET_RECRUITING

Local Institution - 0092, São Paulo

V8R 6V5

NOT_YET_RECRUITING

Local Institution - 0200, Victoria

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre, Toronto

G1J 1Z4

NOT_YET_RECRUITING

Local Institution - 0250, Québec

J1H 5N4

NOT_YET_RECRUITING

Local Institution - 0192, Sherbrooke

WITHDRAWN

Local Institution - 0226, Sherbrooke

010020

RECRUITING

Inner Mongolia Cancer Hospital, Hohhot

00029

NOT_YET_RECRUITING

Local Institution - 0150, Helsinki

44093 Cedex 1

RECRUITING

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes

07747

RECRUITING

Universitätsklinikum Jena, Jena

09116

RECRUITING

Klinikum Chemnitz Ggmbh, Chemnitz

01307

RECRUITING

Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden

681 00

NOT_YET_RECRUITING

Local Institution - 0111, Alexandroupoli

106 76

RECRUITING

Evangelismos General Hospital of Athens, Athens

570 10

NOT_YET_RECRUITING

Local Institution - 0110, Thessaloniki

NOT_YET_RECRUITING

Local Institution - 0197, Thessaloniki

455 00

NOT_YET_RECRUITING

Local Institution - 0108, Ioannina

400 057

NOT_YET_RECRUITING

Local Institution - 0141, Mumbai

466-8560

RECRUITING

Nagoya University Hospital, Nagoya

064-0804

RECRUITING

Aiiku Hospital, Sapporo

670-8540

RECRUITING

Japanease Red Cross Society Himeji Hospital, Himeji

020-0066

RECRUITING

Iwate Prefectural Central Hospital, Morioka

104-0045

RECRUITING

National Cancer Center Hospital, Chuo-ku

173-8610

RECRUITING

Nihon University Itabashi Hospital, Itabashiku

409-3898

RECRUITING

University of Yamanashi Hospital, Chūō

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center, Fukuoka

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

730-0052

RECRUITING

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima

1081 HV

RECRUITING

Amsterdam UMC, locatie VUmc, Amsterdam

9713 GZ

NOT_YET_RECRUITING

Local Institution - 0046, Groningen

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht, Utrecht

60-185

RECRUITING

AIDPORT Sp. z o.o., Skórzewo

30-727

RECRUITING

Pratia MCM Krakow, Krakow

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw

81-519

NOT_YET_RECRUITING

Local Institution - 0190, Gdynia

93-513

NOT_YET_RECRUITING

Local Institution - 0189, Lodz

03080

NOT_YET_RECRUITING

Local Institution - 0059, Seoul

05505

NOT_YET_RECRUITING

Local Institution - 0060, Seoul

06351

NOT_YET_RECRUITING

Local Institution - 0061, Seoul

07345

NOT_YET_RECRUITING

Local Institution - 0058, Seoul

08208

RECRUITING

Hospital Universitari Parc Tauli, Sabadell

06100

NOT_YET_RECRUITING

Local Institution - 0194, Ankara

07059

NOT_YET_RECRUITING

Local Institution - 0196, Antalya

NR4 7UY

RECRUITING

Norfolk and Norwich University Hospitals NHS Foundation Trust, Cringleford

CT1 3NG

RECRUITING

Kent and Canterbury Hospital, Canterbury

W12 0HS

NOT_YET_RECRUITING

Local Institution - 0213, London

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY