NCT06903585View on ClinicalTrials.gov

Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

385

Participants

Timeline

Start Date

April 30, 2025

Primary Completion Date

April 30, 2029

Study Completion Date

April 30, 2029

Conditions
Bone Pain FlareBone Metastasis
Interventions
DRUG

Naproxen (Proxen S)

Naproxen will be given for 5 days starting from the day subjects first receive palliative radiotherapy, it will be taken as an initial dose of 500mg then as 250mg every 8 hours for a total of 5 days.

DRUG

Placebo

Placebo will be given for 5 days starting from the day subjects first receive palliative radiotherapy, it will be given every 8 hours for a total of 5 days.

DRUG

Esomeprazole 20mg once daily

Esomeprazole will be given to all subjects as 20mg once daily starting from the day they start palliative radiotherapy and for a total of 5 days.

Trial Locations (1)

1107 - 2020

American University of Beirut Medical Center, Beirut

All Listed Sponsors
lead

American University of Beirut Medical Center

OTHER