PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis

PHASE4RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
Intracranial AtherosclerosisIntracranial Artery StenosisAtherosclerotic Plaque
Interventions
DRUG

Recaticimab and Statin

Recaticimab (450mg every 12 weeks subcutaneously) combined with rosuvastatin 10mg qn or atorvastatin 20mg qn

DRUG

Statin

Rosuvastatin 10mg qn or atorvastatin 20mg qn

Trial Locations (19)

100730

RECRUITING

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

100853

NOT_YET_RECRUITING

Chinese PLA General Hospital, Beijing

210000

NOT_YET_RECRUITING

Nanjing First Hospital, Nanjing

252000

NOT_YET_RECRUITING

Liaocheng People's Hospital, Liaocheng

261000

NOT_YET_RECRUITING

Weifang People's Hospital, Weifang

272000

NOT_YET_RECRUITING

Jining First People's Hospital, Jining

442000

NOT_YET_RECRUITING

Taihe Hospital, Shiyan

Unknown

NOT_YET_RECRUITING

The Third Affiliated Hospital of Sun Yat-sen University, Yuedong Hospital, Meizhou

NOT_YET_RECRUITING

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou

NOT_YET_RECRUITING

Peking University Third Hospital Qinhuangdao Hospital, Qinhuangdao

NOT_YET_RECRUITING

First Affiliated Hospital of Harbin Medical University, Harbin

NOT_YET_RECRUITING

The first affiliated hospital of zhengzhou university, Zhengzhou

NOT_YET_RECRUITING

Zhongnan Hospital of Wuhan University, Wuhan

NOT_YET_RECRUITING

The Affiliated Hospital of Qingdao University, Qingdao

NOT_YET_RECRUITING

Chongqing General Hospital, Chongqing

NOT_YET_RECRUITING

Huashan Hospital, Fudan University, Shanghai

050051

RECRUITING

Hebei Provincial People's Hospital, Shijiazhuang

063000

NOT_YET_RECRUITING

Tangshan Worker's Hospital, Tangshan

014000

NOT_YET_RECRUITING

Baotou Central Hospital, Baotou

All Listed Sponsors
collaborator

Chinese PLA General Hospital

OTHER

collaborator

Hebei General Hospital

OTHER

collaborator

Taihe Hospital

OTHER

collaborator

Weifang People's Hospital

OTHER

collaborator

Nanjing First Hospital, Nanjing Medical University

OTHER

collaborator

Baotou Central Hospital

OTHER

collaborator

Jining First People's Hospital

OTHER

collaborator

Liaocheng People's Hospital

OTHER

collaborator

Tangshan Worker's Hospital

OTHER

collaborator

Chongqing General Hospital

OTHER

collaborator

First Affiliated Hospital of Harbin Medical University

OTHER

collaborator

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

Zhongnan Hospital

OTHER

collaborator

Huashan Hospital

OTHER

lead

Peking Union Medical College Hospital

OTHER