A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

May 22, 2025

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or CancerLocally Advanced Unresectable Gastric Adenocarcinoma or CancerMetastatic Gastric Adenocarcinoma or CancerMetastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions
DRUG

zolbetuximab

Participants will receive an IV infusion of zolbetuximab on Cycle 1 Day 1 (C1D1) followed by subsequent IV infusion every 2 weeks or every 3 weeks.

DRUG

Pembrolizumab

Participants will receive an IV infusion of pembrolizumab every 3 weeks or every 6 weeks.

DRUG

Capecitabine

Participants receiving CAPOX regimen of chemotherapy will receive capecitabine Tablet twice daily orally on days 1 through 14 and days 22 through 35 of each cycle.

DRUG

Oxaliplatin

Participants receiving CAPOX or mFOLFOX6 regimen of chemotherapy will receive an IV infusion of oxaliplatin once every 2 or 3 weeks.

DRUG

Folinic acid (leucovorin or local equivalent)

Participants receiving mFOLFOX6 regimen of chemotherapy will receive an IV infusion of Folinic acid (leucovorin or local equivalent) once every 2 weeks.

DRUG

5-fluorouracil (5-FU)

Participants receiving mFOLFOX6 regimen of chemotherapy will receive an IV infusion, or IV bolus of 5-FU once every 2 weeks.

DRUG

Placebo

Participants will receive an IV infusion of placebo (0.9% of sodium chloride) on C1D1 followed by subsequent IV infusion every 2 weeks or every 3 weeks.

Trial Locations (78)

10016

RECRUITING

NYU Langone Medical Center, New York

37920

RECRUITING

The University of Tennessee Medical Center, Knoxville

52242

RECRUITING

Holden Comprehensive Cancer Center, Iowa City

55426

RECRUITING

Metro Minnesota Community Oncology Research Consortium (MMCORC), Saint Louis Park

68130

RECRUITING

Oncology Hematology West PC dba Nebraska Cancer Specialists, Omaha

76104

RECRUITING

The Center For Cancer And Blood Disorders (Texas Cancer Care), Fort Worth

02215

RECRUITING

Dana Farber/Harvard Cancer Center, Boston

Unknown

RECRUITING

FR33003, Paris

RECRUITING

FR33010, Paris

RECRUITING

FR33013, Paris

RECRUITING

FR33006, Rouen

RECRUITING

DE49002, Saarbrücken

RECRUITING

DE49011, Schweinfurt

RECRUITING

IT39009, Brescia

RECRUITING

IT39007, Meldola

RECRUITING

Chiba Cancer Center, Chiba

RECRUITING

National Cancer Center Hospital East, Kashiwa

RECRUITING

National Hospital Organization Shikoku Cancer Center, Matsuyama

RECRUITING

Kyushu University Hospital (Hematology, Oncology & Cardiovascular medicine), Fukuoka

RECRUITING

Kyushu University Hospital(Gastrointestinal Surgery), Fukuoka

RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

RECRUITING

Gunma University Hospital, Maebashi

RECRUITING

Hokkaido University Hospital, Sapporo

RECRUITING

Hyogo Cancer Center, Akashi-shi

RECRUITING

Kobe City Medical Center General Hospital, Kobe

RECRUITING

Kagawa University Hospital, Kida-gun

RECRUITING

St. Marianna University Hospital, Kawasaki-shi

RECRUITING

Kanagawa Cancer Ctr Hospital, Yokohama

RECRUITING

Osaka General Medical Center, Osaka

RECRUITING

Osaka University Hospital, Suita-shi

RECRUITING

Saitama Medical University International Medical Center, Hidaka-shi

RECRUITING

Shizuoka Cancer Center, Sunto-gun

RECRUITING

National Cancer Center Hospital, Chuo-ku

RECRUITING

The Cancer Institute Hospital of JFCR, Koto-ku

RECRUITING

LT37001, Kaunas

RECRUITING

LT37002, Vilnius

RECRUITING

NL31001, Nijmegen

RECRUITING

PL48001, Brzozów

RECRUITING

PL48008, Olsztyn

RECRUITING

PL48002, Przemyśl

RECRUITING

PL48007, Warsaw

RECRUITING

RO40001, Cluj-Napoca

RECRUITING

RO40006, Cluj-Napoca

RECRUITING

RO40002, Floreşti

RECRUITING

RO40007, Iași

RECRUITING

RO40004, Timișoara

RECRUITING

KR82011, Goyang-si

RECRUITING

KR82007, Seongnam-si

RECRUITING

KR82013, Suwon

RECRUITING

KR82015, Suwon

RECRUITING

KR82014, Hwasungun

RECRUITING

KR82009, Cheongju-si

RECRUITING

KR82004, Daegu

RECRUITING

KR82005, Incheon

RECRUITING

KR82001, Seoul

RECRUITING

KR82002, Seoul

RECRUITING

KR82006, Seoul

RECRUITING

KR82010, Seoul

RECRUITING

KR82012, Seoul

RECRUITING

ES34027, Madrid

RECRUITING

ES34002, Navarra

RECRUITING

ES34006, Barcelona

RECRUITING

ES34014, Lleida

RECRUITING

ES34008, Madrid

RECRUITING

ES34016, Madrid

RECRUITING

ES34017, Madrid

RECRUITING

ES34013, Pozuelo de Alarcón

RECRUITING

ES34012, Seville

RECRUITING

ES34025, Seville

RECRUITING

ES34004, Valencia

RECRUITING

TW88604, Kaohsiung City

RECRUITING

UK44001, Bristol

RECRUITING

UK44006, Dundee

RECRUITING

UK44011, London

RECRUITING

UK44014, London

RECRUITING

UK44015, London

RECRUITING

UK44016, London

RECRUITING

UK44009, Manchester

All Listed Sponsors
lead

Astellas Pharma Global Development, Inc.

INDUSTRY