TACE Combined Surgery for the Resectable Huge HCC

RecruitingOBSERVATIONAL
Enrollment

326

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
Hepatocellular CarcinomaHepatic ChemotherapyLiver CancerSurgery
Interventions
PROCEDURE

TACE

TACE procedure was a 2.8-F microcatheter was super-selectively inserted into the tumor feeding artery using the coaxial technique. Then a combination of lipiodol (5-15 ml), lobaplatin (30-50 mg), and Pirarubicin (30-50 mg) was infused into each tumor. We defined technical success as complete embolization of the tumor-feeding artery resulting in no tumor staining observed by angiogram at the end of procedure.

PROCEDURE

Surgery

The surgical plan was based on the tumor size, tumor location, and liver function. We applied Pringle's maneuver with cycles of clamping and unclamping times of 1-10 and 5 min, respectively, and maintained the central venous pressure below 4 mmHg during parenchymal dissection to control intraoperative bleeding.

Trial Locations (1)

100853

RECRUITING

Chinese PLA general hospital, Beijing

All Listed Sponsors
lead

Sun Yat-sen University

OTHER