Effect of Intensive Lipid-Lowering Therapy on Coronary Atherosclerotic Plaque Progression in Young and Middle-Aged Patients With Chronic Coronary Syndrome

NANot yet recruitingINTERVENTIONAL
Enrollment

766

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

July 1, 2027

Study Completion Date

March 1, 2028

Conditions
Chronic Coronary Syndrome
Interventions
DRUG

Intensive lipid-lowering strategy

The initial recommended therapy is 20mg atorvastatin/10mg rosuvastatin plus Ezetimibe or PCSK9i, and the type and dosage of drugs can be adjusted according to the situation. If the target LDL-C level is not achieved during the Follow-up periods, adjustment of drug type and dosage will be carried out according to procedures defined in the protocol.

DRUG

Standard lipid-lowering strategy

The initial recommended therapy is 20mg atorvastatin/10mg rosuvastatin, and the type and dosage of drugs can be adjusted according to the situation. If the target L-DLC level is not achieved during the Follow-up periods, adjustment of drug type and dosage will be carried out according to procedures defined in the protocol.

Trial Locations (7)

116000

The First Affiliated Hospital of Dalian Medical University, Dalian

400015

The First Affiliated Hospital of Chongqing Medical University, Chongqing

510000

The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou

510100

Guangdong Provincial People's Hospital, Guangzhou

518033

The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen

523000

The Ninth Clinical Medical College of Guangzhou University of Chinese Medicine, Dongguan

528400

Zhongshan People's Hospital, Zhongshan

All Listed Sponsors
lead

Liu yong

OTHER

NCT06896708 - Effect of Intensive Lipid-Lowering Therapy on Coronary Atherosclerotic Plaque Progression in Young and Middle-Aged Patients With Chronic Coronary Syndrome | Biotech Hunter | Biotech Hunter