A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

PHASE2RecruitingINTERVENTIONAL
Enrollment

594

Participants

Timeline

Start Date

April 11, 2025

Primary Completion Date

December 13, 2027

Study Completion Date

December 16, 2032

Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
BIOLOGICAL

Zilovertamab vedotin

IV infusion

BIOLOGICAL

Rituximab

IV infusion

DRUG

Cyclophosphamide

IV infusion

DRUG

Doxorubicin

IV infusion

BIOLOGICAL

Rituximab Biosimilar

IV infusion

DRUG

Prednisone

Oral administration or IV infusion

DRUG

Prednisolone

Oral administration or IV infusion

BIOLOGICAL

Polatuzumab vedotin

IV infusion

DRUG

Rescue Medication

Participants receive rescue medication at the investigators discretion, per approved product label. Recommended rescue medication is Granulocyte Colony-Stimulating Factor (G-CSF).

Trial Locations (55)

1200

RECRUITING

Cliniques Universitaires Saint-Luc ( Site 0302), Brussels

2800

RECRUITING

AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306), Mechelen

3000

RECRUITING

UZ Leuven ( Site 0301), Leuven

7100

RECRUITING

Hopital de Jolimont ( Site 0304), Haine-Saint-Paul

11590

RECRUITING

Clinical Research Alliance ( Site 0122), Westbury

13100

RECRUITING

ZIV Medical Center ( Site 0605), Safed

14215

RECRUITING

Erie County Medical Center ( Site 0175), Buffalo

15121

RECRUITING

Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703), Alessandria

20089

RECRUITING

Istituto Clinico Humanitas ( Site 0704), Rozzano

20141

RECRUITING

Istituto Europeo di Oncologia ( Site 0701), Milan

27514

RECRUITING

University of North Carolina Medical Center ( Site 0136), Chapel Hill

32763

RECRUITING

Mid Florida Hematology and Oncology Center ( Site 0152), Orange City

33140

RECRUITING

Mount Sinai Cancer Center ( Site 0140), Miami Beach

36607

RECRUITING

Infirmary Cancer Care ( Site 0157), Mobile

40207

RECRUITING

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185), Louisville

40503

RECRUITING

Baptist Health Lexington ( Site 0127), Lexington

41017

RECRUITING

Saint Elizabeth Medical Center Edgewood ( Site 0141), Edgewood

42123

RECRUITING

Arcispedale Santa Maria Nuova ( Site 0706), Reggio Emilia

42701

RECRUITING

Baptist Health Hardin ( Site 0154), Elizabethtown

47014

RECRUITING

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori ( Site 0707)", Meldola

50263

RECRUITING

Mission Blood & Cancer Care ( Site 0114), Waukee

52242

RECRUITING

University of Iowa-Holden Comprehensive Cancer Center ( Site 0139), Iowa City

53715

RECRUITING

SSM Health Dean Medical Group ( Site 0106), Madison

60637

RECRUITING

University of Chicago Medical Center ( Site 0126), Chicago

68198

RECRUITING

University Of Nebraska Medical Center ( Site 0110), Omaha

68506

RECRUITING

NHO Revive Research Institute, LLC ( Site 0121), Lincoln

71913

RECRUITING

Genesis Cancer and Blood Institute ( Site 0193), Hot Springs

75701

RECRUITING

The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145), Tyler

80131

RECRUITING

Universita degli Studi di Napoli Federico II ( Site 0705), Napoli

85304

RECRUITING

Palo Verde Cancer Specialists ( Site 0105), Glendale

90146

RECRUITING

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702), Palermo

94598

RECRUITING

Bass Medical Group ( Site 0123), Walnut Creek

97080

RECRUITING

Universitaetsklinikum Wuerzburg ( Site 0401), Würzburg

3109601

RECRUITING

Rambam Health Care Campus ( Site 0604), Haifa

5265601

RECRUITING

Sheba Medical Center ( Site 0603), Ramat Gan

5810001

RECRUITING

Edith Wolfson Medical Center ( Site 0602), Holon

9112001

RECRUITING

Haddasah Medical Center ( Site 0601), Jerusalem

V94 F858

RECRUITING

University Hospital Limerick ( Site 0503), Limerick

464-8681

RECRUITING

Aichi Cancer Center ( Site 1007), Nagoya

470-1192

RECRUITING

Fujita Health University Hospital ( Site 1003), Toyoake

060-8648

RECRUITING

Hokkaido University Hospital ( Site 1004), Sapporo

983-8520

RECRUITING

National Hospital Organization Sendai Medical Center ( Site 1005), Sendai

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 1006), Hirakata

693-8501

RECRUITING

Shimane University Hospital ( Site 1002), Izumo

113-8603

RECRUITING

Nippon Medical School Hospital ( Site 1001), Bunkyo

104-0045

RECRUITING

National Cancer Center Hospital ( Site 1009), Chūō

852-8501

RECRUITING

Nagasaki University Hospital ( Site 1008), Nagasaki

30-727

RECRUITING

Pratia MCM Krakow ( Site 0804), Karkow

33-300

RECRUITING

Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806), Nowy Sącz

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803), Warsaw

40-519

RECRUITING

Pratia Onkologia Katowice ( Site 0801), Katowice

BS2 8ED

RECRUITING

Bristol Haematology and Oncology Centre ( Site 0908), Bristol

HP21 8AL

RECRUITING

Stoke Mandeville Hospital ( Site 0917), Aylesbury

PL68DH

RECRUITING

University Hospitals Plymouth NHS Trust ( Site 0905), Plymouth

L7 8YA

RECRUITING

Clatterbridge Cancer Centre - Liverpool ( Site 0911), Liverpool

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY