Ondansetron vs. Dexamethasone for Postoperative Nausea

PHASE4CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

March 20, 2025

Primary Completion Date

June 10, 2025

Study Completion Date

June 11, 2025

Conditions
Postoperative Nausea and Vomiting (PONV)
Interventions
DRUG

Placebo (Normal Saline)

Patients in this group will receive an intravenous (IV) injection of normal saline before surgery. This serves as a control group to compare the efficacy of active treatment groups in preventing postoperative nausea and vomiting.

DRUG

Ondansetron (Zofran)

Patients in this group will receive a single intravenous (IV) dose of Ondansetron 4 mg before surgery. Ondansetron is a selective 5-HT3 receptor antagonist commonly used to prevent nausea and vomiting associated with anesthesia and surgery.

DRUG

Dexamethasone

Patients in this group will receive a single intravenous (IV) dose of Dexamethasone 8 mg before surgery. Dexamethasone is a corticosteroid with anti-inflammatory properties that has been shown to reduce the incidence of PONV by modulating inflammatory pathways and neuroreceptor activity.

Trial Locations (1)

051

Federal Government Polyclinic (Postgraduate Medical Institute), Islamabad

All Listed Sponsors
collaborator

Federal Government Polyclinic (Postgraduate Medical Institute)

OTHER

lead

Hafiz Muhammad Hamza

OTHER