Brain Mechanisms of Social Perception in Parkinson's Disease

NARecruitingINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

July 15, 2025

Primary Completion Date

April 30, 2027

Study Completion Date

April 30, 2027

Conditions
Social Perception in Parkinson's Disease
Interventions
BEHAVIORAL

Behavioral task of social perception (stage 1)

Patients with Parkinson disease and healthy volunteer are engaged in a social perception behavioral task.

OTHER

Functional magnetic resonance imaging: 3 Tesla magnetic resonance imaging (stage 2)

"Patients with Parkinson disease and healthy volunteer are assessed by functional magnetic resonance imaging while they are engaged in a social perception behavioral task.~2 times for patients with Parkinson disease (during ON-levodopa and OFF-levodopa) Once for healthy volunteer"

OTHER

Neurological and neuropsychological assessments

Patients with Parkinson disease and healthy volunteer will undergo a neurological and neuropsychological assessment with several evaluations: weight, height, medical history, global cognitive performance (MoCA and BREF score), apathy (LARS score), depression (BDI-II score), social cognition (mini-SEA), and quality of life (PDQ39 self-questionnaire).

OTHER

Neurological assessments of Parkinson's disease symptoms and caregiver burden

Patients with Parkinson disease will undergo a neurological assessment of motor and non-motor symptoms of Parkinson's disease (MDS-UPDRS III \& IV scale and MDS-NMS scale) and caregiver burden (Zarit scale).

Trial Locations (1)

69677

RECRUITING

Service de neurologie - troubles du mouvement et pathologies neuromusculaires, Hôpital neurologique Pierre Wertheimer/GHE, Bron

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT06884722 - Brain Mechanisms of Social Perception in Parkinson's Disease | Biotech Hunter | Biotech Hunter