3,000
Participants
Start Date
March 3, 2025
Primary Completion Date
December 31, 2029
Study Completion Date
June 30, 2033
Blinatumomab
All LR-B-ALL patients will be treated with 14 days of blinatumomab (Blina-14) as early intensification to replace CAT+ (historically given in LR-B-AL with MRD19\>0.1% in the 2020 protocol). Additionally, second 14 days of blinatumomab will be given after completion of HDMTX consolidation treatment.
Reinduction-2 omission
Reinduction-2 will be omitted for patients with NGS-MRD46\<10\^-6 who have receive the two courses of Blina-14.
Chemo-light Maintenance 2
Patients with FCM-MRD19\<0.01% and IgH rearrangement NGS MRD 46\<10\^-6 will receive chemo-light maintenance-2 with 4 cyles of 8-week course of MTX + 6MP (totally 32 weeks).
NOT_YET_RECRUITING
Anhui Medical University Second Affiliated Hospital, Hefei
NOT_YET_RECRUITING
Anhui Provincial Children's Hospital, Hefei
NOT_YET_RECRUITING
Chongqing Medical University Affiliated Children's Hospital, Chongqing
NOT_YET_RECRUITING
Fujian Medical University Union Hospital, Fuzhou
NOT_YET_RECRUITING
Guangzhou Women and Children's Medical Center, Guangzhou
NOT_YET_RECRUITING
Nanfang Hospital, Southern Medical University, Guangzhou
NOT_YET_RECRUITING
The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning
NOT_YET_RECRUITING
The Affiliated Hospital of Guizhou Medical University, Guiyang
NOT_YET_RECRUITING
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Wuhan Children's Hospital, Wuhan
NOT_YET_RECRUITING
Hunan Children's Hospital, Changsha
NOT_YET_RECRUITING
The Third Xiangya Hospital of the Central South University, Changsha
NOT_YET_RECRUITING
Xiangya Hospital Central South University, Changsha
NOT_YET_RECRUITING
Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing
NOT_YET_RECRUITING
Children's Hospital of Soochow University, Suzhou
NOT_YET_RECRUITING
Jiangxi Provincial Children's Hospital, Nanchang
NOT_YET_RECRUITING
Qilu Hospital of Shandong University, Jinan
NOT_YET_RECRUITING
Affiliated Hospital of Qingdao University, Qingdao
NOT_YET_RECRUITING
Children's Hospital of Fudan University, Shanghai
NOT_YET_RECRUITING
Shanghai Children's Hospital, Shanghai
NOT_YET_RECRUITING
Shanghai Children's Medical Cener, Shanghai Jiao Tong University School of Medicine, Shanghai
NOT_YET_RECRUITING
Xi'an Northwest Women and Children Hospital, Xi’an
NOT_YET_RECRUITING
Shenzhen Children's Hospita, Shenzhen
NOT_YET_RECRUITING
West China Second University Hospital, Chengdu
RECRUITING
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin
NOT_YET_RECRUITING
Hong Kong Children's Hospital, Hong Kong
Institute of Hematology & Blood Diseases Hospital, China
OTHER