NCT06881524View on ClinicalTrials.gov

Low-Dose Amoxicillin Dual-Therapy Combined with Licorice and Lotus Root Powder Helicobacter Pylori Treatment

NANot yet recruitingINTERVENTIONAL
Enrollment

374

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

July 1, 2025

Study Completion Date

August 1, 2025

Conditions
HELICOBACTER PYLORI INFECTIONS
Interventions
DRUG

First-line licorice and lotus root powder combined with low-dose amoxicillin

For first-line experimental group, patients would receive vonoprazan 20mg twice daily, amoxicillin 0.75g three times daily for 10 days, licorice and lotus root powder 5.0g twice daily for an additional 6 weeks

DRUG

First line high-dose amoxicillin

For first-line active comparator group, patients would receive vonoprazan 20mg twice daily, amoxicillin 1 g three times daily for 10 days

DRUG

Rescue licorice and lotus root powder combined with low-dose amoxicillin

For rescue experimental group, patients would receive vonoprazan 20mg twice daily, amoxicillin 0.75g three times daily for 10 days, licorice and lotus root powder 5.0g twice daily for an additional 6 weeks

DRUG

Rescue high-dose amoxicillin

For rescue active comparator group, patients would receive vonoprazan 20mg twice daily, amoxicillin 1 g three times daily for 10 days

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

NCT06881524 - Low-Dose Amoxicillin Dual-Therapy Combined with Licorice and Lotus Root Powder Helicobacter Pylori Treatment | Biotech Hunter | Biotech Hunter