1,524
Participants
Start Date
October 25, 2025
Primary Completion Date
March 13, 2028
Study Completion Date
March 13, 2037
Trastuzumab (Herceptin)
Given IV or SC
Pertuzumab
Given IV or SC
Echocardiography
Undergo ECHO
Multigated Acquisition Scan
Undergo MUGA
Mammography
Undergo mammography
Ultrasound
Undergo ultrasound
Magnetic Resonance Imaging
Undergo MRI
Biospecimen Collection
Undergo blood and tissue sample collection
Questionnaire Administration
Ancillary studies
Roswell Park Cancer Institute, Buffalo
Thomas Jefferson University Hospital, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford
Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants PA, Newark
Christiana Care Health System-Christiana Hospital, Newark
Christiana Care Health System-Wilmington Hospital, Wilmington
Beebe Medical Center, Lewes
Beebe South Coastal Health Campus, Millville
Beebe Health Campus, Rehoboth Beach
MedStar Georgetown University Hospital, Washington D.C.
MedStar Washington Hospital Center, Washington D.C.
MedStar Montgomery Medical Center, Olney
Greater Baltimore Medical Center, Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
MedStar Good Samaritan Hospital, Baltimore
Christiana Care - Union Hospital, Elkton
Bon Secours Westchester Emergency Center, Midlothian
Bon Secours Saint Francis Medical Center, Midlothian
Bon Secours Memorial Regional Medical Center, Mechanicsville
Bon Secours Richmond Community Hospital, Richmond
Bon Secours Saint Mary's Hospital, Richmond
Bon Secours Cancer Institute at Reynolds Crossing, Richmond
Edwards Comprehensive Cancer Center, Huntington
Novant Health Colon and Rectal Clinic, Clemmons
Novant Health Cancer Institute - Mount Airy, Mount Airy
Novant Health Forsyth Medical Center, Winston-Salem
Novant Health Cancer Institute - Kernersville, Kernersville
Novant Health Cancer Institute - Thomasville, Thomasville
Novant Health Breast Surgery - Greensboro, Greensboro
Novant Health Cancer Institute - Huntersville, Huntersville
Novant Health Presbyterian Medical Center Huntersville, Huntersville
Matthews Radiation Oncology Center, Matthews
Novant Health Cancer Institute - Matthews, Matthews
Novant Health Cancer Institute - Mooresville, Mooresville
Novant Health Cancer Institute - Rowan, Salisbury
Rowan Regional Medical Center, Salisbury
Novant Health Presbyterian Medical Center, Charlotte
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst
Novant Health Cancer Institute - Statesville, Statesville
Novant Health Cancer Institute - Wilkesboro, North Wilkesboro
Margaret R Pardee Memorial Hospital, Hendersonville
Lexington Medical Center, West Columbia
Sacred Heart Hospital, Pensacola
Jupiter Medical Center, Jupiter
Flaget Memorial Hospital, Bardstown
Saint Joseph Mount Sterling, Mount Sterling
Saint Joseph Hospital, Lexington
Saint Joseph Radiation Oncology Resource Center, Lexington
Saint Joseph Hospital East, Lexington
Commonwealth Cancer Center-Corbin, Corbin
Saint Joseph London, London
Aultman Alliance Community Hospital, Alliance
Aultman Health Foundation, Canton
Good Samaritan Hospital - Cincinnati, Cincinnati
Bethesda North Hospital, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
TriHealth Cancer Institute-Anderson, Cincinnati
UChicago Medicine Northwest Indiana, Crown Point
OSF Saint Francis Hospital and Medical Group, Escanaba
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
McFarland Clinic - Trinity Cancer Center, Fort Dodge
Mercy Hospital, Cedar Rapids
Oncology Associates at Mercy Medical Center, Cedar Rapids
HSHS Saint Nicholas Hospital, Sheboygan
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan
Sheboygan Physicians Group, Sheboygan
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Rapid City Regional Hospital, Rapid City
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Hi-Line Sletten Cancer Center, Havre
Community Hospital of Anaconda, Anaconda
Bozeman Health Deaconess Hospital, Bozeman
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
Northwestern Medicine Glenview Outpatient Center, Glenview
Northwestern Medicine Grayslake Outpatient Center, Grayslake
Northwestern Medicine Lake Forest Hospital, Lake Forest
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Northwestern Medicine Cancer Center Delnor, Geneva
UC Comprehensive Cancer Center at Silver Cross, New Lenox
Northwestern Medicine Orland Park, Orland Park
University of Chicago Medicine-Orland Park, Orland Park
Northwestern Medicine Oak Brook, Oak Brook
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Illinois CancerCare-Dixon, Dixon
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare - Washington, Washington
Illinois CancerCare-Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
Illinois CancerCare-Bloomington, Bloomington
OSF Saint Anthony's Health Center, Alton
Cancer Care Center of O'Fallon, O'Fallon
HSHS Saint Elizabeth's Hospital, O'Fallon
Illinois CancerCare-Carthage, Carthage
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Centralia Oncology Clinic, Centralia
Saint Mary's Hospital, Centralia
SSM Health Good Samaritan, Mount Vernon
Memorial Hospital of Carbondale, Carbondale
SIH Cancer Institute, Carterville
Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin
Missouri Baptist Sullivan Hospital, Sullivan
Mercy Hospital Washington, Washington
Mercy Infusion Center - Chippewa, St Louis
BJC Outpatient Center at Sunset Hills, Sunset Hills
Mercy Hospital South, St Louis
Missouri Baptist Medical Center, St Louis
Mercy Hospital Saint Louis, St Louis
Parkland Health Center - Farmington, Farmington
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
Mercy Cancer Center - Cape Girardeau, Cape Girardeau
Saint Francis Medical Center, Cape Girardeau
Heartland Regional Medical Center, Saint Joseph
Freeman Health System, Joplin
Mercy Hospital Joplin, Joplin
Lake Regional Hospital, Osage Beach
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Central Care Cancer Center - Bolivar, Bolivar
Cox Cancer Center Branson, Branson
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Cancer Center of Kansas - Chanute, Chanute
Mercy Hospital Pittsburg, Pittsburg
Cancer Center of Kansas - El Dorado, El Dorado
Cancer Center of Kansas-Kingman, Kingman
Cancer Center of Kansas - Newton, Newton
Cancer Center of Kansas - Pratt, Pratt
Cancer Center of Kansas - Wellington, Wellington
Cancer Center of Kansas - Winfield, Winfield
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita
Ascension Via Christi Hospitals Wichita, Wichita
Cancer Center of Kansas - Wichita, Wichita
Cancer Center of Kansas-Independence, Independence
Cancer Center of Kansas - Parsons, Parsons
Cancer Center of Kansas - Salina, Salina
Central Care Cancer Center - Great Bend, Great Bend
Cancer Center of Kansas - Dodge City, Dodge City
Central Care Cancer Center - Garden City, Garden City
Cancer Center of Kansas-Liberal, Liberal
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
CHI Health Saint Francis, Grand Island
CHI Health Good Samaritan, Kearney
CARTI Cancer Center, Little Rock
Mercy Hospital Fort Smith, Fort Smith
Mercy Hospital Oklahoma City, Oklahoma City
Saint Anthony North Hospital, Westminster
Saint Anthony Hospital, Lakewood
Longmont United Hospital, Longmont
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Francis Cancer Center, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
CommonSpirit Cancer Center Mercy, Durango
Mercy Medical Center, Durango
Billings Clinic-Cody, Cody
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
Cancer Center at Saint Joseph's, Phoenix
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
Mission Hope Medical Oncology - Santa Maria, Santa Maria
Saint Joseph's Medical Center, Stockton
Mercy Cancer Center, Merced
Mercy Cancer Center - Carmichael, Carmichael
Mercy San Juan Medical Center, Carmichael
Woodland Memorial Hospital, Woodland
Mercy Cancer Center - Elk Grove, Elk Grove
Mercy Cancer Center - Rocklin, Rocklin
Mercy Cancer Center - Sacramento, Sacramento
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital and Medical Center, Portland
Saint Michael Cancer Center, Silverdale
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver
Legacy Salmon Creek Hospital, Vancouver
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER