ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

1,524

Participants

Timeline

Start Date

October 25, 2025

Primary Completion Date

March 13, 2028

Study Completion Date

March 13, 2037

Conditions
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Early Stage Breast Carcinoma
Interventions
BIOLOGICAL

Trastuzumab (Herceptin)

Given IV or SC

BIOLOGICAL

Pertuzumab

Given IV or SC

PROCEDURE

Echocardiography

Undergo ECHO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

PROCEDURE

Mammography

Undergo mammography

PROCEDURE

Ultrasound

Undergo ultrasound

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Biospecimen Collection

Undergo blood and tissue sample collection

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (206)

14263

Roswell Park Cancer Institute, Buffalo

19107

Thomas Jefferson University Hospital, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19967

Beebe South Coastal Health Campus, Millville

19971

Beebe Health Campus, Rehoboth Beach

20007

MedStar Georgetown University Hospital, Washington D.C.

20010

MedStar Washington Hospital Center, Washington D.C.

20832

MedStar Montgomery Medical Center, Olney

21204

Greater Baltimore Medical Center, Baltimore

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21239

MedStar Good Samaritan Hospital, Baltimore

21921

Christiana Care - Union Hospital, Elkton

23113

Bon Secours Westchester Emergency Center, Midlothian

23114

Bon Secours Saint Francis Medical Center, Midlothian

23116

Bon Secours Memorial Regional Medical Center, Mechanicsville

23223

Bon Secours Richmond Community Hospital, Richmond

23226

Bon Secours Saint Mary's Hospital, Richmond

23230

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

25701

Edwards Comprehensive Cancer Center, Huntington

27012

Novant Health Colon and Rectal Clinic, Clemmons

27030

Novant Health Cancer Institute - Mount Airy, Mount Airy

27103

Novant Health Forsyth Medical Center, Winston-Salem

27284

Novant Health Cancer Institute - Kernersville, Kernersville

27360

Novant Health Cancer Institute - Thomasville, Thomasville

27403

Novant Health Breast Surgery - Greensboro, Greensboro

28078

Novant Health Cancer Institute - Huntersville, Huntersville

Novant Health Presbyterian Medical Center Huntersville, Huntersville

28105

Matthews Radiation Oncology Center, Matthews

Novant Health Cancer Institute - Matthews, Matthews

28117

Novant Health Cancer Institute - Mooresville, Mooresville

28144

Novant Health Cancer Institute - Rowan, Salisbury

Rowan Regional Medical Center, Salisbury

28204

Novant Health Presbyterian Medical Center, Charlotte

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28625

Novant Health Cancer Institute - Statesville, Statesville

28659

Novant Health Cancer Institute - Wilkesboro, North Wilkesboro

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29169

Lexington Medical Center, West Columbia

32504

Sacred Heart Hospital, Pensacola

33458

Jupiter Medical Center, Jupiter

40004

Flaget Memorial Hospital, Bardstown

40353

Saint Joseph Mount Sterling, Mount Sterling

40504

Saint Joseph Hospital, Lexington

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

44601

Aultman Alliance Community Hospital, Alliance

44710

Aultman Health Foundation, Canton

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

46307

UChicago Medicine Northwest Indiana, Crown Point

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

53081

HSHS Saint Nicholas Hospital, Sheboygan

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan

Sheboygan Physicians Group, Sheboygan

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

57701

Rapid City Regional Hospital, Rapid City

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59501

Hi-Line Sletten Cancer Center, Havre

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60026

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60523

Northwestern Medicine Oak Brook, Oak Brook

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62002

OSF Saint Anthony's Health Center, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

Saint Mary's Hospital, Centralia

62864

SSM Health Good Samaritan, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Mercy Infusion Center - Chippewa, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65065

Lake Regional Hospital, Osage Beach

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps Health Delbert Day Cancer Institute, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66720

Cancer Center of Kansas - Chanute, Chanute

66762

Mercy Hospital Pittsburg, Pittsburg

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67530

Central Care Cancer Center - Great Bend, Great Bend

67801

Cancer Center of Kansas - Dodge City, Dodge City

67846

Central Care Cancer Center - Garden City, Garden City

67905

Cancer Center of Kansas-Liberal, Liberal

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68803

CHI Health Saint Francis, Grand Island

68847

CHI Health Good Samaritan, Kearney

72205

CARTI Cancer Center, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73120

Mercy Hospital Oklahoma City, Oklahoma City

80023

Saint Anthony North Hospital, Westminster

80228

Saint Anthony Hospital, Lakewood

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

CommonSpirit Cancer Center Mercy, Durango

Mercy Medical Center, Durango

82414

Billings Clinic-Cody, Cody

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85004

Cancer Center at Saint Joseph's, Phoenix

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

95204

Saint Joseph's Medical Center, Stockton

95340

Mercy Cancer Center, Merced

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95816

Mercy Cancer Center - Sacramento, Sacramento

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

98383

Saint Michael Cancer Center, Silverdale

98684

Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver

98686

Legacy Salmon Creek Hospital, Vancouver

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER