Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Ischemic Stroke

PHASE3RecruitingINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

April 12, 2025

Primary Completion Date

March 10, 2026

Study Completion Date

June 30, 2026

Conditions
Ischemic Stroke
Interventions
DRUG

PPA Intervention

"Participants in this group will receive a pharmacological cocktail (PPA) for five days in addition to standard medical treatment for acute ischemic stroke. The regimen includes terazosin or urapidil, and propranolol or esmolol, with individualized blood pressure management. The specific protocol is as follows:~* Terazosin (no less than 1 mg orally or via nasogastric tube, nightly) or Urapidil (100 mg in 30 mL saline, IV infusion at no less than 2 mL/h)~* Propranolol (10 mg orally or via nasogastric tube, three times daily) or Esmolol (1 g in 40 mL saline, IV infusion at no less than 2 mL/h; use for no more than 48 hours. Beyond 48 hours, switch to Propranolol)"

Trial Locations (1)

310000

RECRUITING

Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER