Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

42,000

Participants

Timeline

Start Date

February 28, 2025

Primary Completion Date

March 28, 2028

Study Completion Date

March 28, 2028

Conditions
Cardiovascular Diseases (CVD)Drug EffectAtherosclerosis Cardiovascular Disease
Interventions
DRUG

Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)

Participants will be instructed to take their Statin daily at approx. 8PM-12AM.

DRUG

Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)

Participants will be instructed to take their statin upon awakening/or with their breakfast (approx. 6AM-10AM).

Trial Locations (1)

2900

Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Hellerup

All Listed Sponsors
collaborator

Herlev and Gentofte Hospital

OTHER

lead

Tor Biering-Sørensen

OTHER