Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS

NARecruitingINTERVENTIONAL
Enrollment

780

Participants

Timeline

Start Date

April 7, 2025

Primary Completion Date

October 31, 2027

Study Completion Date

January 31, 2028

Conditions
Acute Respiratory Distress Syndrome
Interventions
PROCEDURE

Daily prone position sessions

Prone position sessions will be extended at least 16 hours, but no longer than 24 hours. Prone sessions will be repeated if PaO2/FiO2 ratio decreases to \< 150 after returning to supine position within the first 7 days after randomization. The extension of repeated prone sessions will follow the same criteria.

PROCEDURE

Prolonged prone position sessions

Prone position sessions will be extended at least 48 hours AND until PaO2/FiO2 ratio is ≥ 200, but no longer than 120 hours. Prone sessions will be repeated if PaO2/FiO2 ratio decreases to \< 150 after returning to supine position within the first 7 days after randomization. The extension of repeated prone sessions will follow the same criteria.

Trial Locations (6)

Unknown

RECRUITING

Hospital Guillermo Grant Benavente, Concepción

RECRUITING

Complejo Asistencial Dr. Victor Ríos Ruiz, Los Ángeles

RECRUITING

Hospital de Quilpué, Quilpué

RECRUITING

Clínica Las Condes, Santiago

RECRUITING

Hospital Clínico UC Christus, Santiago

RECRUITING

Hospital Clínico Universidad de Chile, Santiago

All Listed Sponsors
collaborator

Hospital do Coracao

OTHER

collaborator

Fundacion Clinica Valle del Lili

OTHER

collaborator

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

OTHER_GOV

lead

Pontificia Universidad Catolica de Chile

OTHER