Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

PHASE4RecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions
Preoperative AnxietyPreoperative SedationChildrenDexmedetomidineEsketamineED95ED50Preoperative Sedation of Children
Interventions
DRUG

dexmedetomidine

esketamine 0.5mg/kg intranasally via a nasal dropper, dexmedetomidine 1μg/kg was given intranasally, and the adjusted dose of dexmedetomidine was 0.25μg/kg.

DRUG

Esketamine

esketamine 0.5mg/kg intranasally via a nasal dropper, dexmedetomidine 1μg/kg was given intranasally, and the adjusted dose of dexmedetomidine was 0.25μg/kg.

Trial Locations (2)

325000

NOT_YET_RECRUITING

The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou

RECRUITING

The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou

All Listed Sponsors
lead

Second Affiliated Hospital of Wenzhou Medical University

OTHER