Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients

NARecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

December 15, 2025

Study Completion Date

December 30, 2025

Conditions
Laparoscopic SurgeryPositive End-Expiratory PressureElectrical Impedance Tomography
Interventions
DEVICE

electrical impedance tomography

The individualized high PEEP with RMs group commences with a PEEP of 5 cm H2O and undergo an RM followed by a decremental PEEP trial. Pressure-controlled ventilation mode is set with a respiratory rate of 16 breaths per minute and ΔP=15 (ΔP is calculated by subtracting PEEP from the plateau pressure (Pplat). In intervals of 5 breaths, PEEP is incrementally increased by 5 cm H2O, starting at 5 cm H2O and reaching up to 20 cm H2O. The decremental PEEP trial is immediately performed following the first RM, beginning at a PEEP of 20 cm H2O with a respiratory rate of 15 breaths per minute. Every 30 seconds, PEEP is decreased by increments of 2 cm H2O until it reaches a minimum of 6 cm H2O. This decremental PEEP trial is succeeded by a second RM, after which the individualized PEEP level will be established as determined by the decremental PEEP trial and sustained until the completion of ventilation.

DEVICE

Conventional Ventilation

Ventilation is set in volume-controlled mode with a tidal volume of 7 ml/kg predicted body weight (PBW), the respiratory rate is adjusted to target normocapnia (end-tidal carbon dioxide partial pressure between 35 and 45 mmH), an inspiratory to expiratory ratio of 1:2, and a PEEP of 5 cmH2O.

Trial Locations (1)

10000

RECRUITING

Anesthesia Center, Bach Mai Hospital, Hanoi

All Listed Sponsors
collaborator

Bach Mai Hospital

OTHER

collaborator

Hanoi Medical University

OTHER

lead

Nguyen Dang Thu

OTHER