NCT06849570View on ClinicalTrials.gov

Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol

NANot yet recruitingINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

April 1, 2028

Study Completion Date

April 1, 2029

Conditions
Acute Respiratory Distress Syndrome (ARDS)Intensive Care Units (ICUs)
Interventions
OTHER

Minimal distension

Patients receive tidal volume (VT) of 6 mL/kg and conservative positive end-expiratory pressure (PEEP) setting.

OTHER

Maximal Recruitment

Patients receive tidal volume adjusted to limit plateau pressure (∆P) to 14 cmH2O and the highest possible PEEP while maintaining plateau pressure (PPLAT) ≤ 27 cmH2O.

OTHER

Prone position + early NMBAs

NMBAs given as soon as possible after randomization

OTHER

Prone position + rescue NMBAs

NMBAs given only as a rescue

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER

NCT06849570 - Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol | Biotech Hunter | Biotech Hunter