Study of Emotional Dysregulation in Complex Post-Traumatic Stress Disorder

NANot yet recruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

March 1, 2027

Study Completion Date

December 1, 2027

Conditions
Complex Post-Traumatic Stress Disorder (CPTSD)Borderline Personality Disorder (BPD)Post-traumatic Stress Disorder (PTSD)
Interventions
OTHER

Self-questionnaires

All subjects (healthy volunteers and all patients) will complete a battery of self-questionnaires, assessing emotional dysregulation, traumatic symptoms, alteration of the sense of self, sensitivity to social rejection, dissociative symptoms, child abuse, functional repercussions of the disorders, depressive and anxiety symptoms and Impulsivity.

OTHER

Cognitive assessment

Completion of cognitive assessment, consisting of verbal fluency tasks , emotional Hayling, a dissociative associative memory retrieval task, a negative priming task and a heart rhythm detection task. The tasks of associative-dissociative memory retrieval, negative priming and heart rhythm detection will be coupled with a physiological recording, via a Biopac, to measure the change in skin conductance, body temperature and heart rate. The negative priming task will also be associated with the recording of eye movements allowing an indirect measurement of attentional orientation.

OTHER

Momentary Ecological Assessment (EMA)

A momentary ecological evaluation protocol will be proposed (between visits V1 and V2 for all subjects and between V3 and V4 for the 4 groups of patients) in order to assess emotional and symptomatic dynamics in a daily life context through a connected wath. During 7 days, subjects will be invited, via their smartphone, to carry out daily semi-random readings (indicated by smartphone notifications) of their subjective emotional experiences (10 once/day), but also spontaneous (by reporting emotions deemed intense immediately afterwards that they take place).

OTHER

Semi-structured interviews ITI and DSCID-II

"ITI International Trauma Interview is a semi-structured interview consisting of one part allocated to the description of a traumatic event and two parts addressing the symptoms of PTSD (i.e. reliving, avoidance and alteration of wakefulness) and the symptoms of the disturbance of self-organization.~The SCID-II Structured Clinical Interview for DSM-IV Personality Disorder is a 90-item semi-structured interview, covering all 10 categories of personality disorder as described in the DSM-IV."

All Listed Sponsors
lead

University Hospital, Strasbourg, France

OTHER

NCT06848127 - Study of Emotional Dysregulation in Complex Post-Traumatic Stress Disorder | Biotech Hunter | Biotech Hunter