A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

PHASE3RecruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

April 10, 2025

Primary Completion Date

May 15, 2028

Study Completion Date

February 14, 2030

Conditions
CLLChronic Lymphocytic Leukemia
Interventions
DRUG

BGB-16673

Administered orally

DRUG

Bendamustine

Administered intravenously

DRUG

Idelalisib

Administered orally

DRUG

Rituximab

Administered intravenously

DRUG

Venetoclax

Administered orally

Trial Locations (125)

1413

NOT_YET_RECRUITING

Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires

1425

NOT_YET_RECRUITING

Hospital Aleman, CABA

1426

NOT_YET_RECRUITING

Instituto Alexander Fleming (Iaf), Ciudad Autonoma Buenos Aires

6129

NOT_YET_RECRUITING

Ospedale Santa Maria Della Misericordia, Perugia

6500

NOT_YET_RECRUITING

Gazi University, Ankara

10000

NOT_YET_RECRUITING

Vseobecna Fakultni Nemocnice V Praze, Prague

10408

NOT_YET_RECRUITING

National Cancer Center (Korea), IlsandongGu GoyangSi

10715

NOT_YET_RECRUITING

Praxis Am Volkspark, Berlin

15224

NOT_YET_RECRUITING

West Penn Hospital, Pittsburgh

20122

NOT_YET_RECRUITING

Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico, Milan

20132

NOT_YET_RECRUITING

Ospedale San Raffaele, Milan

20251

NOT_YET_RECRUITING

Universitatsklinikum Hamburg Eppendorf, Hamburg

27100

NOT_YET_RECRUITING

Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi, Pavia

28100

RECRUITING

Aou Maggiore Della Carita, Novara

33912

NOT_YET_RECRUITING

Florida Oncology and Hematology, Fort Myers

35330

NOT_YET_RECRUITING

Dokuz Eylul University, Balçova

41944

NOT_YET_RECRUITING

Kyungpook National University Hospital, Junggu

45122

NOT_YET_RECRUITING

Universitatsklinikum Essen (Aor), Essen

48149

NOT_YET_RECRUITING

Universitatsklinikum Munster Medizinische Klinik A, Münster

49201

RECRUITING

Dong A University Hospital, Seogu

50134

RECRUITING

Aou Careggi, Servizio Sanitario Toscana, Florence

54100

NOT_YET_RECRUITING

Sakarya Training and Research Hospital, Sakarya

56068

RECRUITING

Invo Institut Fur Versorgungsforschung in Der Onkologie, Koblenz

58128

NOT_YET_RECRUITING

Chonnam National University Hwasun Hospital, HwasunGun

60389

NOT_YET_RECRUITING

Centrum Fur Haematologie Und Onkologie Bethanien, Frankfurt am Main

66421

NOT_YET_RECRUITING

Saarland University Medical Center, Homburg

69120

NOT_YET_RECRUITING

Universitatsklinikum Heidelberg, Heidelberg

70124

RECRUITING

Irccs Istituto Tumori Giovanni Paolo Ii, Bari

72401

NOT_YET_RECRUITING

St Bernards Medical Center, Jonesboro

79104

NOT_YET_RECRUITING

Universitatsklinikum Freiburg I Br Klinik Fur Innere Medizin I, Freiburg im Breisgau

80131

NOT_YET_RECRUITING

Azienda Ospedaliera Universitaria Federico Ii, Napoli

86156

NOT_YET_RECRUITING

Universitatsklinikum Augsburg, Augsburg

90602

NOT_YET_RECRUITING

Pih Health Whittier Hospital, Whittier

93049

NOT_YET_RECRUITING

Krankenhaus Der Barmherzigen Bruder, Regensburg

97401

NOT_YET_RECRUITING

Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene

90095-3075

NOT_YET_RECRUITING

UCLA Department of Medicine Hematologyoncology, Los Angeles

80012-5405

NOT_YET_RECRUITING

Rocky Mountain Cancer Centers (Williams) Usor, Aurora

33331-3609

NOT_YET_RECRUITING

Cleveland Clinic Florida, Weston

30322-1013

NOT_YET_RECRUITING

Emory University Winship Cancer Institute, Atlanta

70808-4365

NOT_YET_RECRUITING

Our Lady of the Lake Hospital, Baton Rouge

20817-7847

NOT_YET_RECRUITING

American Oncology Partners of Maryland Pa, Bethesda

49503-2560

NOT_YET_RECRUITING

Corewell Health the Michigan Cancer Consortium, Grand Rapids

65807-5288

NOT_YET_RECRUITING

Oncology Hematology Associates, Springfield

68130-2042

RECRUITING

Oncology Hematology West, Pc Dba Nebraska Cancer Specialists, Omaha

10065-6800

NOT_YET_RECRUITING

Memorial Sloan Kettering Cancer Center Mskcc, New York

11590-5119

NOT_YET_RECRUITING

Clinical Research Alliance, Inc, Westbury

44106-1716

SUSPENDED

University Hospitals, Cleveland

17403-5049

RECRUITING

Cancer Care Associates of York, York

75702-7522

NOT_YET_RECRUITING

Texas Oncology Tyler, Tyler

26003-6379

NOT_YET_RECRUITING

Wvu Medicine, Wheeling Hospital, Wheeling

CP1114

NOT_YET_RECRUITING

FUNDALEU, Caba

NSW 2139

RECRUITING

Concord Repatriation General Hospital, Concord

NSW 2250

NOT_YET_RECRUITING

Gosford Hospital, Gosford

NSW 2444

NOT_YET_RECRUITING

Port Macquarie Base Hospital, Port Macquarie

QLD 4350

RECRUITING

Toowoomba Hospital, Toowoomba

SA 5042

NOT_YET_RECRUITING

Flinders Medical Centre, Bedford PK

VIC 3004

RECRUITING

The Alfred Hospital, Melbourne

WA 6005

RECRUITING

Perth Blood Institute, West Perth

30110-022

RECRUITING

CETUS, Belo Horizonte

70200-730

NOT_YET_RECRUITING

Hospital Sirio Libanes Brasilia, Brasília

81520-060

NOT_YET_RECRUITING

Hospital Erasto Gaertner, Curitiba

88020-210

RECRUITING

Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen), Florianópolis

89201-260

RECRUITING

Instituto Joinvilense de Hematologia E Oncologia, Joinville

24020-096

NOT_YET_RECRUITING

Complexo Hospitalar de Niteroi, Niterói

90110-270

NOT_YET_RECRUITING

Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre

52011-906

NOT_YET_RECRUITING

Hospital Santa Joana Recife, Recife

22061-080

NOT_YET_RECRUITING

Hospital Sao Lucas Dasa Oncologia, Rio de Janeiro

22250-040

RECRUITING

Oncoclinicas Rio de Janeiro Sa, Rio de Janeiro

41253-190

NOT_YET_RECRUITING

Hospital Sao Rafael (Rede Dor), Salvador

04014-002

RECRUITING

Instituto Brasileiro de Controle Do Cancer, São Paulo

04501-000

RECRUITING

Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo

05653-120

RECRUITING

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

29043-260

RECRUITING

Hospital Santa Rita de Cassia Afecc, Vitória

N6A 5W9

NOT_YET_RECRUITING

London Health Sciences Centre, London

K1H 8L6

NOT_YET_RECRUITING

The Ottawa Hospital Cancer Centre, Ottawa

J4V 2H1

NOT_YET_RECRUITING

Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre, Greenfield Park

QC H3t 1E2

NOT_YET_RECRUITING

Jewish General Hospital, Montreal

J7Z 5T3

NOT_YET_RECRUITING

Unite de Recherche Clinique Du Cisss Des Laurentides, SaintJerome

625 00

NOT_YET_RECRUITING

Fakultni Nemocnice Brno, Brno

500 03

RECRUITING

Fakultni Nemocnice Hradec Kralove, Hradec Králové

708 00

NOT_YET_RECRUITING

Fakultni Nemocnice Ostrava, Ostrava

09116

NOT_YET_RECRUITING

Klinikum Chemnitz Ggmbh, Chemnitz

04103

NOT_YET_RECRUITING

Universitaetsklinikum Leipzig Aor, Leipzig

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli, Roma

464-8681

NOT_YET_RECRUITING

Aichi Cancer Center Hospital Clinical Oncology, Nagoya

260-8717

NOT_YET_RECRUITING

Chiba Cancer Center, Chiba

277-8577

NOT_YET_RECRUITING

National Cancer Center Hospital East, Kashiwa

791-0280

NOT_YET_RECRUITING

Nho Shikoku Cancer Center, Matsuyama

730-8619

RECRUITING

Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima

064-0804

RECRUITING

Aiiku Hospital, Sapporo

660-8550

RECRUITING

Hyogo Prefectural Amagasaki General Medical Center, AmagasakiCity

890-8520

RECRUITING

Kagoshima University Hospital, Kagoshima

602-8566

RECRUITING

University Hospital, Kyoto Prefectural Univ of Medicine, KyotoShi

980-8574

NOT_YET_RECRUITING

Tohoku University Hospital, Sendai

951-8520

RECRUITING

Niigata University Medical and Dental Hospital, Niigata

710-8602

NOT_YET_RECRUITING

Kurashiki Central Hospital, Kurashikishi

573-1191

NOT_YET_RECRUITING

Kansai Medical University Hospital, Hirakata

589-8511

NOT_YET_RECRUITING

Kindai University Hospital, Sayama

350-8550

RECRUITING

Saitama Medical Center, Kawagoeshi

141-0022

NOT_YET_RECRUITING

Ntt Medical Center Tokyo, Shinagawaku

860-8556

RECRUITING

Kumamoto University Hospital, Kumamoto

701-1192

RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

545-8586

NOT_YET_RECRUITING

Osaka Metropolitan University Hospital, Osaka

1081 HV

NOT_YET_RECRUITING

Amsterdam Umc Vu Mc, Amsterdam

6525 GA

NOT_YET_RECRUITING

Radboud Universitair Medisch Centrum, Nijmegen

0622

NOT_YET_RECRUITING

North Shore Hospital, Auckland

36-200

NOT_YET_RECRUITING

Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny, Brzozów

40-519

RECRUITING

Pratia Onkologia Katowice, Katowice

30-727

RECRUITING

Pratia McM Krakow, Krakow

93-513

RECRUITING

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz

20-090

RECRUITING

Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin

50-367

RECRUITING

Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu, Wroclaw

06351

RECRUITING

Samsung Medical Center, GangnamGu

06591

RECRUITING

The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu

03080

RECRUITING

Seoul National University Hospital, Seoul

06200

NOT_YET_RECRUITING

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara

07025

RECRUITING

Antalya Memorial Hospital, Dokuma

AB25 2ZN

NOT_YET_RECRUITING

Aberdeen Royal Infirmary, Aberdeen

B9 5SS

NOT_YET_RECRUITING

Birmingham Heartlands Hospital, Birmingham

BH7 7DW

NOT_YET_RECRUITING

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth

OX3 7LE

NOT_YET_RECRUITING

Churchill Hospital Oxford University Hospital Nhs Trust, Headington

NW1 2PG

RECRUITING

University College Hospital, London

SW3 6JJ

NOT_YET_RECRUITING

Royal Marsden Hospital, London

NG5 1PB

NOT_YET_RECRUITING

Nottingham University Hospitals Nhs Trust, Nottingham

SO16 6YD

NOT_YET_RECRUITING

Southampton General Hospital, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT06846671 - A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors | Biotech Hunter | Biotech Hunter