NCT06845592View on ClinicalTrials.gov

Safely Delivered Targeted High-dose Irradiation Followed by Adoptive Immunotherapy with Regulatory and Conventional T Cells to Increase Potency of Hematopoietic Stem Cell Transplantation in High-risk Acute Leukemia

NARecruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

February 25, 2025

Primary Completion Date

January 31, 2029

Study Completion Date

January 31, 2031

Conditions
Acute Myeloid Leukaemia (AML)Acute Lymphoblastic Leukemia ALLHigh Risk LeukaemiaLeukaemia Relapse
Interventions
RADIATION

total marrow/lymphoid irradiation

Combination of 20 Gy TMLI with Treg/Tcon adoptive immunotherapy in allogeneic cell transplantation

Trial Locations (1)

06100

RECRUITING

Università degli Studi di Perugia, Perugia

All Listed Sponsors
lead

University Of Perugia

OTHER