Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

PHASE2RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

February 11, 2025

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
AphasiaStrokeAphasia Following Cerebral InfarctionAphasia, Acquired
Interventions
DEVICE

Transcranial Magnetic Stimulation (TMS)

TMS, is a form of non-invasive brain stimulation, that uses magnetic pulses to stimulate specific areas of the brain. In this study we will utilize theta-burst stimulation which uses a higher frequency pulse of 50 Hz delivered for 40 seconds for a total of 600 pulses.

BEHAVIORAL

Speech-Language Therapy (SLT)

"Our SLT protocol draws from two theories and evidence-based cognitive-linguistic frameworks: (1) conversational alignment, which engages priming of lexical and syntactic structures through dialogue and conversation and (2) increased tolerance of memory load in the context of sentence repetition and dialogue tasks. Administration of these tasks will abide by principles of constraint-induced language therapy, i.e., intense treatment schedule and verbal responding only.~All participants will receive SLT."

Trial Locations (1)

19014

RECRUITING

University of Pennsylvania, Philadelphia

All Listed Sponsors
collaborator

Temple University

OTHER

collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

lead

University of Pennsylvania

OTHER