Spermatogonial Differentiation Via Testicular Organoid

Primary cell cultures of tissue cells will be established. Cell cultures will undergo genetic reprogramming to induce the long-term propagation of living cells.

Serum samples are processed through RNA sequencing to reveal known and novel infertility-related biomarkers and genes.

Genes or gene products will be reinserted into cells to observe how the cells can be changed, or reprogrammed, into embryonic-like cells or into sperm precursor cells.

Genetically unmodified and modified cells are placed in a laboratory-based testicular environment to promote spermatogenesis into maturity.