A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

March 16, 2025

Primary Completion Date

May 18, 2030

Study Completion Date

May 18, 2030

Conditions
Triple Negative Breast Neoplasms
Interventions
BIOLOGICAL

Sacituzumab tirumotecan

IV Infusion

BIOLOGICAL

Pembrolizumab

IV Infusion

DRUG

Rescue Medication

Participants receive the following pre-medications before sacituzumab tirumotecan infusion: Histamine-1 (H1) receptor agonist, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion. Participants are also recommended to receive prophylactic steroid mouthwash (dexamethasone or equivalent).

DRUG

Paclitaxel

IV Infusion

DRUG

Nab-paclitaxel

IV Infusion

DRUG

Gemcitabine

IV Infusion

DRUG

Carboplatin

IV Infusion

Trial Locations (173)

104

RECRUITING

Mackay Memorial Hospital ( Site 5301), Taipei

333

RECRUITING

Chang Gung Memorial Hospital ( Site 5302), Taoyuan District

407

RECRUITING

Taichung Veterans General Hospital ( Site 5303), Taichung

1023

RECRUITING

Harbour Cancer & Wellness ( Site 5600), Newmarket

2148

RECRUITING

Blacktown Hospital ( Site 5500), Blacktown

2610

RECRUITING

ZAS Sint Augustinus ( Site 3102), Antwerp

6035

RECRUITING

Bowen Hospital ( Site 5601), Wellington

9000

RECRUITING

AZ Maria Middelares ( Site 3103), Ghent

RECRUITING

UZ Gent ( Site 3101), Ghent

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center ( Site 0003), New York

10408

RECRUITING

National Cancer Center ( Site 5202), Goyang-si

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 5800), Bangkoknoi

11501

RECRUITING

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0073), Mineola

13620

RECRUITING

Seoul National University Bundang Hospital ( Site 5204), Seongnam

15036

RECRUITING

Clínica Internacional - Sede San Borja ( Site 2604), Lima

RECRUITING

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 2601), Lima

RECRUITING

Oncosalud ( Site 2600), Lima

15076

RECRUITING

Hospital Militar Central Coronel Luis Arias Schereiber ( Site 2603), Lima

20832

RECRUITING

MedStar Montgomery Medical Center ( Site 0078), Olney

20910

RECRUITING

Holy Cross Hospital ( Site 0091), Silver Spring

21237

RECRUITING

MedStar Franklin Square Medical Center ( Site 0031), Baltimore

21239

RECRUITING

MedStar Good Samaritan Hospital ( Site 0079), Baltimore

23502

RECRUITING

Virginia Oncology Associates (VOA) ( Site 8002), Norfolk

27607

RECRUITING

UNC REX Cancer Center ( Site 0071), Raleigh

28007

RECRUITING

Hospital Beata María Ana ( Site 4105), Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal ( Site 4103), Madrid

28040

RECRUITING

Hospital Clinico San Carlos ( Site 4100), Madrid

30607

RECRUITING

University Cancer & Blood Center, LLC ( Site 0023), Athens

31123

RECRUITING

Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 2510), Chihuahua City

32701

RECRUITING

AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007), Altamonte Springs

33401

RECRUITING

Florida Cancer Specialists - East ( Site 7000), West Palm Beach

34298

RECRUITING

Institut Regional du Cancer Montpellier ( Site 3009), Montpellier

36604

RECRUITING

USA Mitchell Cancer Institute ( Site 0090), Mobile

37203

RECRUITING

SCRI Oncology Partners ( Site 7004), Nashville

40002

RECRUITING

Faculty of Medicine - Khon Kaen University ( Site 5802), Khon Kaen

41013

RECRUITING

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 4104), Seville

41404

RECRUITING

Kyungpook National University Chilgok Hospital ( Site 5205), Daegu

44805

RECRUITING

Institut De Cancerologie De L Ouest ( Site 3003), Saint-Herblain

46014

RECRUITING

Hospital General Universitario de Valencia ( Site 4102), Valencia

50034

RECRUITING

Instituto de Cancerología ( Site 2206), Medellín

55407

RECRUITING

Allina Health Cancer Institute ( Site 0069), Minneapolis

59100

RECRUITING

Pantai Hospital Kuala Lumpur ( Site 5402), Kuala Lumpur

RECRUITING

University Malaya Medical Centre ( Site 5403), Kuala Lumpur

60612

RECRUITING

University of Illinois Cancer Center ( Site 0044), Chicago

62250

RECRUITING

National Cancer Institute ( Site 5401), Putrajaya

66220

RECRUITING

Oncare - Unidad Valle ( Site 2502), San Pedro Garza García

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca ( Site 2503), Oaxaca City

70403

RECRUITING

National Cheng Kung University Hospital ( Site 5304), Tainan City

75015

RECRUITING

Hôpital Européen Georges Pompidou ( Site 3011), Paris

75231

RECRUITING

Texas Oncology - DFW ( Site 8007), Dallas

76038

RECRUITING

Centre Henri Becquerel ( Site 3001), Rouen

78240

RECRUITING

Texas Oncology - San Antonio ( Site 8001), San Antonio

79902

RECRUITING

Texas Oncology - West Texas ( Site 8004), El Paso

83712

RECRUITING

St. Luke's Cancer Institute: Boise ( Site 0037), Boise

83800

RECRUITING

HIA Sainte Anne ( Site 3007), Toulon

85224

RECRUITING

Ironwood Cancer & Research Centers ( Site 0036), Chandler

87000

RECRUITING

Clinique Francois Chenieux ( Site 3006), Limoges

87109

RECRUITING

New Mexico Oncology Hematology Consultants Ltd. ( Site 0019), Albuquerque

89119

RECRUITING

Comprehensive Cancer Centers of Nevada ( Site 0015), Las Vegas

89502

RECRUITING

Renown Regional Medical Center ( Site 0005), Reno

90095

RECRUITING

UCLA Department of Medicine - Hematology & Oncology ( Site 0047), Los Angeles

90110

RECRUITING

Songklanagarind hospital ( Site 5801), Hat Yai

93586

RECRUITING

Sarawak General Hospital ( Site 5400), Kuching

94158

RECRUITING

UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0016), San Francisco

100225

RECRUITING

National Taiwan University Hospital ( Site 5300), Taipei

100337

RECRUITING

Spitalul Municipal Schuller Ploiești ( Site 4707), Ploieşti

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2203), Bogotá

130021

RECRUITING

The First Hospital of Jilin University ( Site 5003), Changchun

200542

RECRUITING

"Centrul de Oncologie Sfântul Nectarie ( Site 4702)", Craiova

210029

RECRUITING

Jiangsu Province Hospital ( Site 5009), Nanjing

221009

RECRUITING

Xuzhou Central Hospital ( Site 5036), Xuzhou

230002

RECRUITING

IMAT S.A.S ( Site 2202), Montería

233004

RECRUITING

The First Afflilated Hospital of Bengbu Medical College ( Site 5022), Bengbu

250013

RECRUITING

Jinan Central Hospital ( Site 5031), Jinan

276000

RECRUITING

LinYi Cancer Hospital ( Site 5021), Linyi

300239

RECRUITING

Cabinet Medical Oncomed ( Site 4704), Timișoara

310003

RECRUITING

The First Affiliated Hospital Zhejiang University School of Medicine ( Site 5026), Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital ( Site 5012), Hangzhou

310052

RECRUITING

The Second Affiliated hospital of Zhejiang University school of medicine ( Site 5024), Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province ( Site 5029), Linhai

361003

RECRUITING

The First Affiliated hospital of Xiamen University ( Site 5035), Xiamen

400015

RECRUITING

Institutul Oncologic Cluj ( Site 4701), Cluj-Napoca

400016

RECRUITING

The First Affiliated Hospital of Chongqing Medical University ( Site 5039), Chongqing

404000

RECRUITING

Chongqing University Three Gorges Hospital ( Site 5020), Chongqing

407280

RECRUITING

S.C. Radiotherapy Center Cluj S.R.L ( Site 4705), Comuna Floresti

430030

RECRUITING

Tongji Hospital Tongji Medical Science & Technology ( Site 5007), Wuhan

441021

RECRUITING

Xiangyang Central Hospital ( Site 5017), Xiangyang

450008

RECRUITING

Henan Cancer Hospital ( Site 5001), Zhengzhou

510060

RECRUITING

Sun Yat-Sen University Cancer Center ( Site 5014), Guangzhou

530201

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital. ( Site 5008), Nanning

610041

RECRUITING

Sichuan Cancer Hospital. ( Site 5018), Chengdu

641099

RECRUITING

The Second People's Hospital of Neijiang ( Site 5016), Neijiang

660001

RECRUITING

Oncologos Del Occidente ( Site 2208), Pereira

710061

RECRUITING

The First Affiliated Hospital of Xi an Jiaotong University ( Site 5005), Xi'an

830011

RECRUITING

Affiliated Tumor Hospital of Xinjiang Medical University ( Site 5006), Ürümqi

1720430

RECRUITING

IC La Serena Research ( Site 2007), La Serena

2520598

RECRUITING

ONCOCENTRO APYS ( Site 2005), Viña del Mar

3109601

RECRUITING

Rambam Health Care Campus ( Site 3700), Haifa

4070196

RECRUITING

Biocenter ( Site 2009), Concepción

4941492

RECRUITING

Rabin Medical Center ( Site 3702), Petah Tikva

5265601

RECRUITING

Sheba Medical Center ( Site 3701), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 3703), Tel Aviv

7500921

RECRUITING

FALP ( Site 2000), Santiago

7620002

RECRUITING

Clínica UC San Carlos de Apoquindo ( Site 2008), Santiago

8420383

RECRUITING

Bradfordhill ( Site 2001), Santiago

9103102

RECRUITING

Shaare Zedek Medical Center ( Site 3704), Jerusalem

06510

RECRUITING

Yale New Haven Hospital ( Site 0001), New Haven

07601

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0082), Hackensack

B7600FZN

RECRUITING

Instituto de Investigaciones Clinicas Mar del Plata ( Site 2401), Mar del Plata

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 2402), Mar del Plata

R8500ACE

RECRUITING

Clinica Viedma ( Site 2403), Viedma

S2000DEJ

RECRUITING

Fundacion Estudios Clinicos ( Site 2405), Rosario

S2002KDS

RECRUITING

Hospital Provincial del Centenario ( Site 2410), Rosario

X5004BAL

RECRUITING

Hospital Italiano de Cordoba ( Site 2406), Córdoba

M5500AYB

RECRUITING

Fundacion Centro Oncologico de Integración Regional ( Site 2400), Mendoza

+61359860776

RECRUITING

Rosebud Hospital ( Site 5501), Rosebud West

50040-000

RECRUITING

Hospital de Câncer de Recife ( Site 2300), Recife

59062-000

RECRUITING

Liga Norte Riograndense Contra o Cancer ( Site 2310), Natal

14784-400

RECRUITING

Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 2307), Barretos

15090-000

RECRUITING

Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 2301), São Jose Do Rio Preto

04014-002

RECRUITING

IBCC - Núcleo de Pesquisa e Ensino ( Site 2306), São Paulo

L1G 2B9

RECRUITING

Lakeridge Health ( Site 0217), Oshawa

M2K 1E1

RECRUITING

North York General Hospital ( Site 0209), Toronto

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre ( Site 0202), Toronto

G7H 5H6

RECRUITING

CIUSSS- saguenay-Lac-Saint-Jean ( Site 0213), Chicoutimi

H2X 3E4

RECRUITING

Centre Hospitalier de l'Université de Montréal ( Site 0208), Montreal

H3T 1E2

RECRUITING

Jewish General Hospital ( Site 0203), Montreal

H3T 1M5

RECRUITING

St. Marys Hospital Center ( Site 0201), Montreal

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 0204), Montreal

G1S 4L8

RECRUITING

Hopital Du Saint-Sacrement ( Site 0210), Québec

080001

RECRUITING

Centro Cancerologico del Caribe LTD ( Site 2209), Barranquilla

467-8602

RECRUITING

Nagoya City University Hospital ( Site 5108), Nagoya

060-8648

RECRUITING

Hokkaido University Hospital ( Site 5100), Sapporo

259-1193

RECRUITING

Tokai University Hospital ( Site 5107), Isehara

241-8515

RECRUITING

Kanagawa Cancer Center ( Site 5106), Yokohama

514-8507

RECRUITING

Mie University Hospital ( Site 5109), Tsu

565-0871

RECRUITING

The University of Osaka Hospital ( Site 5111), Suita

350-1298

RECRUITING

Saitama Medical University International Medical Center ( Site 5116), Hidaka

113-8431

RECRUITING

Juntendo University Hospital ( Site 5104), Bunkyo

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 5102), Koto

142-8666

RECRUITING

Showa Medical University Hospital ( Site 5103), Shinagawa

162-8655

RECRUITING

National Center for Global Health and Medicine ( Site 5105), Shinjuku

960-1295

RECRUITING

Fukushima Medical University Hospital ( Site 5101), Fukushima

730-8518

RECRUITING

Hiroshima City Hiroshima Citizens Hospital ( Site 5113), Hiroshima

892-0833

RECRUITING

Social medical corporation Hakuaikai Sagara Hospital ( Site 5114), Kagoshima

606-8507

RECRUITING

Kyoto University Hospital ( Site 5110), Kyoto

700-8558

RECRUITING

Okayama University Hospital ( Site 5118), Okayama

541-8567

RECRUITING

Osaka International Cancer Institute ( Site 5112), Osaka

03100

RECRUITING

Grupo Médico ASSET ( Site 2507), Mexico City

6815 AD

RECRUITING

Ziekenhuis Rijnstate ( Site 4501), Arnhem

5022 GC

RECRUITING

ETZ Elisabeth ( Site 4504), Tilburg

7416 SE

RECRUITING

Deventer Ziekenhuis ( Site 4503), Deventer

3015 GD

RECRUITING

Erasmus Medisch Centrum ( Site 4505), Rotterdam

3813 TZ

RECRUITING

Meander Medisch Centrum ( Site 4500), Amersfoort

61-866

RECRUITING

Wielkopolskie Centrum Onkologii-Oddział Onkologii Klinicznej i Immunoonkologii z Pododdziałem Dzien ( Site 3811), Poznan

85-796

RECRUITING

Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 3802), Bydgoszcz

30-727

RECRUITING

Pratia MCM Krakow ( Site 3812), Krakow

08-110

RECRUITING

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3801), Siedlce

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Site 3803), Warsaw

05-135

RECRUITING

Mazowiecki Szpital Onkologiczny ( Site 3807), Wieliszew

81-519

RECRUITING

Szpitale Pomorskie Sp. z o. o. ( Site 3805), Gdynia

75-581

RECRUITING

Szpital Wojewodzki im.M.Kopernika. ( Site 3800), Koszalin

011171

RECRUITING

Spitalul Clinic Filantropia ( Site 4703), Bucharest

077190

RECRUITING

Centrul Medical Neolife- Baneasa ( Site 4706), Bucharest

03080

RECRUITING

Seoul National University Hospital ( Site 5200), Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System ( Site 5201), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 5203), Seoul

08908

RECRUITING

ICO L Hospitalet ( Site 4101), L'Hospitalet de Llobregat

08003

RECRUITING

Parc de Salut Mar - Hospital del Mar ( Site 4106), Barcelona

TR13LJ

RECRUITING

Royal Cornwall Hospital ( Site 4003), Truro

EC1A7BE

RECRUITING

St Bartholomew's Hospital ( Site 4001), London

NW1 2PG

RECRUITING

University College London Hospital ( Site 4007), London

NG51PB

RECRUITING

Nottingham University Hospital NHS Trust ( Site 4009), Nottingham

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY