Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

January 20, 2025

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2025

Conditions
TBI Traumatic Brain Injury
Interventions
DRUG

control

Patients will receive standard care with no interventions until end of treatment.

DRUG

propranolol

starting at 20mg propranolol three times daily by mouth or per feeding tube. The dose was increased daily in 20mg three times daily increments (60mg/day total) until heart rate (HR) was less than 100 beats per minute (bpm) with maximum dose of 640mg/day in addition to standard care until end of treatment.

DRUG

Carvedilol

starting at 6.25mg carvedilol three times daily by mouth or per feeding tube. The dose was increased daily in 6.25 mg three times daily increments (18.75 mg/day total) until heart rate (HR) was less than 100 beats per minute (bpm) with maximum dose of 100 mg/day in addition to standard care until end of treatment.

Trial Locations (2)

Unknown

RECRUITING

Zagazig University Hospitals, Zagazig,, Zagazig

NOT_YET_RECRUITING

Zagazig University Hospitals, Zagazig

All Listed Sponsors
lead

Mansoura University

OTHER