Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Versus Medical Rate Control

NARecruitingINTERVENTIONAL
Enrollment

266

Participants

Timeline

Start Date

September 10, 2025

Primary Completion Date

May 31, 2029

Study Completion Date

December 31, 2029

Conditions
Heart Failure With Preserved Ejection FractionAtrial Fibrillation, Persistent
Interventions
PROCEDURE

pacemaker implantation

The Medtronic 3830 lead should be used as the Conduction System Pacing lead. However, in case of unsuccessful implantation with the 3830 lead, a stylet-driven lead can be used as an alternative.

PROCEDURE

atrioventricular node ablation

Right-sided atrioventricular junction ablation will be attempted first with a radiofrequency catheter. The choice of the catheter will be at the discretion of the physician. The catheter will be advanced to the His Bundle and then slightly withdrawn proximally and caudally in order to target the compact atrioventricular node. Repeated ablation procedures will be recommended during follow-up if regression of atrioventricular block occurs.

DEVICE

Pacemaker programming

The pacemaker device will be programmed in VVIR mode at a lower rate of 75 beats per minute in bipolar mode for sensing and pacing

Trial Locations (15)

1340

NOT_YET_RECRUITING

Clinique St Pierre Ottignies, Ottignies-Louvain-la-Neuve

3000

NOT_YET_RECRUITING

UZ Leuven, Leuven

9300

NOT_YET_RECRUITING

OLV Aalst, Aalst

14000

NOT_YET_RECRUITING

CHRU de Caen, Caen

17019

NOT_YET_RECRUITING

Groupe Hospitalier La Rochelle-Ré-Aunis, La Rochelle

29200

NOT_YET_RECRUITING

CHRU de Brest - Hôpital de la Cavale Blanche, Brest

33604

NOT_YET_RECRUITING

CHU de Bordeaux - Hôpital Cardiologique du Haut-Lévèque, Pessac

34000

NOT_YET_RECRUITING

Clinique Millenaire, Montpellier

37170

NOT_YET_RECRUITING

CHRU de Tours - Trousseau, Chambray-lès-Tours

38043

NOT_YET_RECRUITING

CHU Grenoble Alpes, Grenoble

44093

NOT_YET_RECRUITING

CHU de Nantes - Hôpital Nord Laennec, Nantes

59000

NOT_YET_RECRUITING

CHRU Lille, Lille

59462

NOT_YET_RECRUITING

GHICL Allome - Hôpital St Philibert, Lomme

76000

NOT_YET_RECRUITING

CHU de Rouen, Rouen

86021

RECRUITING

CHU Poitiers, Poitiers

Sponsors
All Listed Sponsors
collaborator

Medtronic France SAS

INDUSTRY

collaborator

ClinSearch

OTHER

lead

French Cardiology Society

OTHER