Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

PHASE3Not yet recruitingINTERVENTIONAL

Enrollment

238

Participants

Timeline

Start Date

March 31, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2029

Conditions

Rectal Cancer

Interventions

DRUG

AK104 plus

SCRT followed by 6 cycles of cadonilimab (AK104) plus mFOLFOX6 as neoadjuvant therapy for patients

DRUG

Chemo only

Short-course radiation (SCRT) followed by 6 cycles of mFOLFOX6 as neoadjuvant therapy for patients

All Listed Sponsors

lead

Wan He

OTHER