Adjusted High-dose Chemotherapy With Autologous Stem Cell Transplant vs. Conventional Immunochemotherapy in Elderly PCNSL Patients

PHASE3RecruitingINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

August 9, 2023

Primary Completion Date

August 31, 2029

Study Completion Date

August 31, 2031

Conditions
Primary Central Nervous System Lymphoma
Interventions
DRUG

R-MP and Procarbazine maintenance

Firstline systemic treatment with conventinal immunochemotherapy (3 cycles of Rituximab-MTX-Procarbazine) followed by Procarbazine maintenance

DRUG

R-MTX/AraC (MARTA) induction followed by consolidating HCT-ASCT

Firstline systemic treatment with age-adjusted MTX based induction (2 cycles of Rituximab-Methotrexate-Cytarabin) followed by consolidating aged-adapted high-dose chemotherapy and autologous stem cell transplantation

Trial Locations (35)

70174

RECRUITING

Klinikum Stuttgart, Clinic of Hematology, Oncology and Palliative Care, Stuttgart Cancer Center / Tumor Center Eva Mayr-Stihl, Stuttgart

79106

RECRUITING

University Hospital Freiburg, Department Medicine I, Hematology, oncology and stem cell transplantation, Freiburg im Breisgau

Unknown

RECRUITING

University Hospital Aachen, Aachen

RECRUITING

University Hospital Augsburg, Augsburg

NOT_YET_RECRUITING

Helios Klinikum Berlin-Buch, Berlin

RECRUITING

University Hospital Berlin, Berlin

NOT_YET_RECRUITING

Evangelisches Klinikum Bethel, Bielefeld

RECRUITING

Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum

RECRUITING

Städtisches Klinikum Braunschweig gGmbH, Braunschweig

RECRUITING

Klinikum Bremen-Mitte gGmbH, Bremen

NOT_YET_RECRUITING

Klinikum Chemnitz gGmbH, Chemnitz

NOT_YET_RECRUITING

Universitätsklinikum Köln, Cologne

RECRUITING

Carl Gustav Carus Universitätsklinikum Dresden, Dresden

NOT_YET_RECRUITING

Universitätsklinikum Düsseldorf, Düsseldorf

RECRUITING

Universitätsklinikum Erlangen, Erlangen

NOT_YET_RECRUITING

Universitätsklinikum Essen, Essen

RECRUITING

Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt

NOT_YET_RECRUITING

Universitätsmedizin Göttingen Georg-August-Universität, Göttingen

NOT_YET_RECRUITING

Universitätsklinikum Halle (Saale), Halle

RECRUITING

Universitätsklinikum des Saarlandes Homburg, Homburg

RECRUITING

Städtisches Klinikum Karlsruhe, Karlsruhe

RECRUITING

Universitätsklinkum Schleswig-Holstein, Campus Kiel, Kiel

RECRUITING

Gemeinschaftsklinikum Mittelrhein gGmbH - Koblenz Ev. Stift St. Martin, Koblenz

NOT_YET_RECRUITING

Universitätsklinikum Leipzig, Leipzig

RECRUITING

Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck

NOT_YET_RECRUITING

Klinikum rechts der Isar TU München, München

RECRUITING

Universitätsklinikum Münster, Münster

NOT_YET_RECRUITING

Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Nuremberg

RECRUITING

Pius-Hospital Oldenburg, Oldenburg

NOT_YET_RECRUITING

Klinikum Oldenburg gGmbh, Oldenburg in Holstein

RECRUITING

Universitätsklinikum Regensburg, Regensburg

NOT_YET_RECRUITING

Universitätsmedizin Rostock, Rostock

NOT_YET_RECRUITING

Universtitätsklinikum Tübingen, Tübingen

RECRUITING

Universitätsklinikum Ulm, Ulm

RECRUITING

Schwarzwald-Baar-Klinikum Villingen-Schwenningen, Villingen-Schwenningen

All Listed Sponsors
collaborator

German Federal Ministry of Education and Research

OTHER_GOV

collaborator

University Hospital Tuebingen

OTHER

collaborator

Heinrich-Heine University, Duesseldorf

OTHER

collaborator

Klinikum Stuttgart

OTHER

collaborator

University of Kaiserslautern

OTHER

collaborator

University Hospital Munich

OTHER

collaborator

University Hospital Regensburg

OTHER

lead

University Hospital Freiburg

OTHER