The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias

NAEnrolling by invitationINTERVENTIONAL
Enrollment

175

Participants

Timeline

Start Date

November 5, 2021

Primary Completion Date

April 15, 2026

Study Completion Date

January 1, 2027

Conditions
Alzheimer DiseaseLewy Body Dementia (LBD)Mild Alzheimer DiseaseFrontotemporal Dementia (FTD)Mild Cognitive Impairment (MCI)Healthy Subjects
Interventions
DIAGNOSTIC_TEST

Electroencephalogram

EEGs will be acquired to explore progressive alteration of EEG patterns throughout the neuropathology progression.

DIAGNOSTIC_TEST

3 Tesla MRI

MRI evaluations will be performed to investigate structural alterations and resting state functional MRI (RS-fMRI) connectivity in participants. Longitudinal measures of cortical/subcortical atrophy and RS-fMRI connectivity will be assessed and their relationship with EEG parameters will be explored.

GENETIC

Apolipoprotein E genetic test

At baseline, a sample of blood will be collected to perform genetic analysis (APOE alleles) for all participants

Trial Locations (1)

20132

IRCCSS San Raffaele, Milan

All Listed Sponsors
lead

IRCCS San Raffaele

OTHER