175
Participants
Start Date
November 5, 2021
Primary Completion Date
April 15, 2026
Study Completion Date
January 1, 2027
Electroencephalogram
EEGs will be acquired to explore progressive alteration of EEG patterns throughout the neuropathology progression.
3 Tesla MRI
MRI evaluations will be performed to investigate structural alterations and resting state functional MRI (RS-fMRI) connectivity in participants. Longitudinal measures of cortical/subcortical atrophy and RS-fMRI connectivity will be assessed and their relationship with EEG parameters will be explored.
Apolipoprotein E genetic test
At baseline, a sample of blood will be collected to perform genetic analysis (APOE alleles) for all participants
IRCCSS San Raffaele, Milan
IRCCS San Raffaele
OTHER