Icaritin in Combination With AG in Patients With Previously Untreated Advanced Pancreatic Ductal Adenocarcinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

April 1, 2027

Study Completion Date

October 1, 2027

Conditions
Advanced Pancreatic Ductal Adenocarcinoma
Interventions
DRUG

Icaritin

"Icaritin soft capsules, 600 mg, taken twice daily, should be swallowed with warm water within 30 minutes after breakfast and dinner. If a patient misses a dose and cannot take it within 2 hours after a meal, they should continue with the next scheduled dose without needing to make up for the missed dose.~Gemcitabine, 1000 mg/m², is administered on days 1 and 8, followed by a 14-day pause, constituting a 21-day treatment cycle. Nab-paclitaxel, 125 mg/m², is also administered on days 1 and 8, with a 14-day pause, making up a 21-day treatment cycle."

DRUG

AG chemotherapy

"Gemcitabine (1000 mg/m²) + saline (100 mL), infused intravenously over 30 minutes, followed by a 100 mL saline flush.~Nab-paclitaxel (125 mg/m²) + saline (100 mL), infused intravenously over 30 minutes, followed by a 100 mL saline flush"

Trial Locations (6)

310000

RECRUITING

Sir Run Run Shaw Hospital, Hangzhou

325000

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

410021

NOT_YET_RECRUITING

Hunan Provincial People's Hospital, Changsha

430079

NOT_YET_RECRUITING

Hubei Cancer Hospital, Wuhan

450003

RECRUITING

Henan Provincial People's Hospital, Zhengzhou

510120

NOT_YET_RECRUITING

Sun Yat-sen Memorial Hospital, Guangzhou

All Listed Sponsors
lead

Sir Run Run Shaw Hospital

OTHER