Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

126

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

December 31, 2025

Study Completion Date

March 20, 2026

Conditions
EsketamineOne-lung VentilationOxygenation Indices
Interventions
DRUG

Esketamine

A total of 126 patients undergoing thoracoscopic surgery under elective general anesthesia were randomly divided into three groups: normal saline group (group C), dexmedetomidine group (group D), eschloroacetone group (group E) and dexmedetomidine group (group D), with 42 cases in each group. Group C was continuously injected with the same amount of normal saline, group D was given dextrometin 1 ug/kg load 10min before surgery, and maintained at 0.4 ug/kg\*h after intubation until 30min before the end of surgery. Group E was given esketamine 0.2 mg/kg 10min before surgery, and maintained at 0.15 mg/kg\*h after intubation until 30min before surgery. Other anesthetic induction and maintenance drugs were consistent among the three groups.

DRUG

Dexmedetomidine

group D was given Dexmedetomidine 1 ug/kg load 10min before surgery, and maintained at 0.4 ug/kg\*h after intubation until 30min before the end of surgery.

DRUG

Normal Saline

Group C was continuously injected with the same amount of normal saline,

Trial Locations (1)

Unknown

The First Affiliated Hospital of Kunming Medical University, Kunming

All Listed Sponsors
lead

Jinqiao Qian

OTHER