Clinical Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of LM-108 ± Penpulimab+Chemotherapy in Advanced Solid Tumors - Cohort C

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

February 28, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2028

Conditions
Advanced Pancreatic Cancer
Interventions
DRUG

LM-108 injection

LM-108 injection is a monoclonal antibody that selectively clears regulatory T cells that infiltrate tumor sites.

DRUG

Penpulimab injection

Penpulimab injection is a Programmed Cell Death Protein 1 (PD-1) immune checkpoint inhibitor.

DRUG

Paclitaxel for injection (albumin bound)

Paclitaxel for injection (albumin bound) is a cytotoxic anticancer drug

DRUG

Gemcitabine hydrochloride for injection

Gemcitabine hydrochloride for injection is a cell cycle specific anti-tumor drug that can inhibit the growth of tumor cells and belongs to a type of chemotherapy drug.

Trial Locations (16)

100005

Peking Union Medical College Hospital, Beijing

100021

Cancer Hospital Chinese Academy of Medical Science, Beijing

100142

Beijing Cancer Hospital, Beijing

110000

The First Affiliated Hospital of China Medical University, Shenyang

110002

The Sixth People's Hospital of Shenyang, Shenyang

150081

Harbin Medical University Cancer Hospital, Harbin

200336

The First Affiliated Hospital of Naval Medical University, Shanghai

210000

Jiangsu Cancer Hospital, Nanjing

Jiangsu Provincial People's Hospital, Nanjing

300000

Tianjin Cancer Hospital Airport Hospital, Tianjin

Tianjin Medical University Cancer Institute & Hospital, Tianjin

330006

The First Affiliated Hospital of Nanchang University, Nanchang

400013

Chongqing Qeneral Hospital, Chongqing

430000

Huazhong University of Science and Technology Tongji Medical College of Huazhong University of Science and Technology, Wuhan

450000

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

710000

The First Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY