A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

PHASE3RecruitingINTERVENTIONAL
Enrollment

425

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
Moderately to Severely Active Crohns Disease
Interventions
DRUG

Afimkibart

Afimkibart will be administered as IV infusion. Afimkibart will be administered as SC injection.

DRUG

Placebo

Placebo matching IV afimkibart.

Trial Locations (112)

1000

RECRUITING

CHU St Pierre (St Pierre), Brussels

1062

RECRUITING

Észak-Pesti Centrumkórház-Honvédkórház, Budapest

1082

RECRUITING

Semmelweis Egyetem, Budapest

1090

RECRUITING

UZ Brussel, Brussels

1200

RECRUITING

Cliniques Universitaires St-Luc, Brussels

2109

RECRUITING

Macquarie University Hospital, Macquarie Park

3011

NOT_YET_RECRUITING

Footscray Hospital, Footscray

3050

RECRUITING

Royal Melbourne Hospital, Parkville

4003

RECRUITING

Multiprofile Hospital Sveti Ivan Rilski, Plovdiv

4010

RECRUITING

Ordensklinikum Linz Barmherzige Schwestern, Linz

4600

RECRUITING

Klinikum Wels-Grieskirchen, Wels

4740

RECRUITING

Coral Sea Clinical Research Institute, Mackay

9700

RECRUITING

Vas-Oxy Egeszsegugyi Kft, Szombathely

11215

RECRUITING

Ellipsis Research Group, Brooklyn

11366

RECRUITING

Intercity Gastroenterology, Fresh Meadows

20815

RECRUITING

Chevy Chase Clinical Research, Chevy Chase

21202

RECRUITING

Mercy Medical Center, Baltimore

25701

RECRUITING

University Physicians and Surgeons Inc, dba Marshall Health, Huntington

28207

RECRUITING

Charlotte Gastroenterology and Hepatology, P.L.L.C, Charlotte

28922

RECRUITING

Fundacion Hospital de Alcorcon, Alcorcón

31000

RECRUITING

Borzan Polyclinic, Osijek

32127

RECRUITING

Advanced Medical Research Center, Port Orange

32825

RECRUITING

Digestive and Liver Center of Florida, Orlando

33027

RECRUITING

Eminat Research Group, Miramar

33033

RECRUITING

Homestead Associates in Research, Inc., Miami

33126

RECRUITING

J&A Clinical Research, Doral

33141

RECRUITING

Miami Beach Clinical Research Center, Miami Beach

33155

RECRUITING

Allied Biomedical Research Institute, Inc, Miami

34295

RECRUITING

Hopital Saint-Eloi, Montpellier

37024

RECRUITING

IRCCS Ospedale Sacro Cuore Don Calabria, Negrar

37170

RECRUITING

CHU Tours - Hôpital Trousseau, Chambray-lès-Tours

39232

RECRUITING

Gastrointestinal Associates Research, Flowood

40138

RECRUITING

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti, Bologna

45431

RECRUITING

Clinical Inquest Center, Beavercreek

49519

RECRUITING

Gastroenterology Associates of Western Michigan, P.L.C., Wyoming

50009

RECRUITING

Hospital Clinico Univ. Lozano Blesa, Zaragoza

54511

RECRUITING

Hôpital de Brabois Adultes, Vandœuvre-lès-Nancy

59037

RECRUITING

CHRU de Lille - Hopital Claude Huriez, Lille

63000

RECRUITING

CHU Clermont Ferrand - Hôpital d'Estaing, Clermont-Ferrand

69495

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

71105

RECRUITING

Louisiana Research Center - GastroIntestinal Associates, Shreveport

75044

RECRUITING

GI Alliance, Garland

75475

RECRUITING

Hôpital Saint-Louis, Paris

75708

RECRUITING

University of Texas Health Center at Tyler, Tyler

78212

RECRUITING

Carta - Clinical Associates In Research Therapeutics Of America;LLC, San Antonio

80907

RECRUITING

Peak Gastroenterology Associates, Colorado Springs

85304

RECRUITING

Sun City Clinical Research, Glendale

85925

RECRUITING

CH Dptal Les Oudairies, La Roche-sur-Yon

87042

RECRUITING

Hopital Dupuytren, Limoges

91355

RECRUITING

Amicis Research Center, Santa Clarita

92200

ACTIVE_NOT_RECRUITING

Institut des MICI, Clinique Ambroise Paré, Neuilly-sur-Seine

93534

RECRUITING

Om Research LLC, Lancaster

94000

RECRUITING

Hôpital Henri Mondor, Créteil

100730

RECRUITING

Beijing Union Hospital, Beijing

110004

RECRUITING

Shengjing Hospital of China Medical University, Shenyang

110221

RECRUITING

Clínica de la Mujer, Bogotá

200092

RECRUITING

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

212001

RECRUITING

Affiliated Hospital of Jiangsu University, Zhenjiang

215004

RECRUITING

The Second Affiliated Hospital of Soochow University, Suzhou

230002

RECRUITING

Oncomedica S.A., Montería

321013

RECRUITING

Jinhua municipal central hospital, Jinhua

330008

RECRUITING

The Second Affiliated Hospital of Nanchang University, Nanchang

341000

RECRUITING

First Affiliated Hospital of Gannan Medical University, Ganzhou

361003

RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

500003

RECRUITING

Yashoda Hospitals, Secunderabad

500032

RECRUITING

AIG Hospitals, Gachibowli

510180

RECRUITING

Guangzhou First People's Hospital, Guangzhou

510280

RECRUITING

Zhujiang Hospital, Southern Medical University, Guangzhou

570311

RECRUITING

Hainan General Hospital, Haikou

610072

RECRUITING

Sichuan Provincial People's Hospital, Chengdu

650032

RECRUITING

The First Affilliated Hospital of Kunming Medical University, Kunming

710004

RECRUITING

The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an

8330034

RECRUITING

Centro de Investigación Clínica UC-CICUC, Santiago

9103102

RECRUITING

Shaare Zedek Medical Center, Jerusalem

37212-1375

RECRUITING

Vanderbilt University Medical Center, Nashville

T4000DPK

RECRUITING

CICE 9 de Julio, San Miguel de Tucumán

27258-000

RECRUITING

Instituto Lobus Unimed Volta Redonda, Volta Redonda

90035-000

RECRUITING

Hospital Moinhos de Vento, Porto Alegre

49055-000

RECRUITING

Newdata Clinical Trials, Aracaju

17210-190

RECRUITING

CECIP - Centro de Estudos Clínicos do Interior Paulista, Jaú

15090-000

RECRUITING

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01308-050

RECRUITING

Hospital Sírio-Libanês, São Paulo

L4M 7G1

RECRUITING

Barrie GI Associates, Barrie

N6A 5A5

RECRUITING

London Health Sciences Centre Uni Campus, London

M6A 3B4

RECRUITING

Toronto Immune and Digestive Health Institute, North YORK

Unknown

RECRUITING

Huizhou First Hospital, Huizhou

050004

RECRUITING

Hebei Medical University - The Second Hospital, Shijiazhuang

000472

RECRUITING

Hospital Universitario San Ignacio, Bogotá

500 12

RECRUITING

Hepato-Gastroenterologie HK, s.r.o., Hradec Králové

708 52

RECRUITING

Fakultni nemocnice Ostrava, Ostrava - Poruba

140 21

RECRUITING

Institutu Klinicke a Experimentaini Mediciny (IKEM);Klinika hepatogastroenterologie, Prague

170 04

RECRUITING

ISCARE a.s., Prague

00128

RECRUITING

Policlinico Universitario Campus Biomedico Di Roma, Rome

00168

RECRUITING

Policlinico Universitario Agostino Gemelli, Rome

85-231

RECRUITING

Medical Center Kermed, Bydgoszcz

44-190

RECRUITING

MZ Badania Slowik Zymla Sp.j., Knurów

31-513

RECRUITING

Centrum Medyczne Promed, Krakow

20-582

RECRUITING

Medrise sp z o.o, Lublin

60-309

RECRUITING

EMC Instytut Medyczny SA, Późna

61-441

RECRUITING

Gabinety Lekarskie Rivermed, Późna

61-731

RECRUITING

Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka Komandytowa, Późna

81-756

RECRUITING

Endoskopia Sp. z o.o., Sopot

00-189

RECRUITING

Centrum Zdrowia-MDM, Warsaw

52-210

RECRUITING

PlanetMed sp. z o.o., Wroc?aw

4710-243

RECRUITING

Hospital de Braga, Braga

1649-035

RECRUITING

Hospital de Santa Maria, Lisbon

4202-451

RECRUITING

Hospital de Sao Joao, Porto

4520-211

RECRUITING

Centro Hospitalar de Entre Douro e Vouga - H. São Sebastião, Santa Maria da Feira

3504-509

RECRUITING

Hospital Sao Teotonio, Viseu

BL9 7TD

RECRUITING

Fairfield General Hospital, Bury

SY23 1ER

RECRUITING

Bronglais General Hospital, Llanrhystud

E1 1FR

RECRUITING

Royal London Hospital, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY