A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

PHASE3RecruitingINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

March 17, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2033

Conditions
Moderately to Severely Active Crohns Disease
Interventions
DRUG

Afimkibart

Afimkibart will be administered as IV infusion. Afimkibart will be administered as SC injection.

DRUG

Placebo

Placebo matching IV afimkibart. Placebo matching SC afimkibart.

Trial Locations (249)

100

RECRUITING

National Taiwan University Hospital, Taipei

1020

RECRUITING

Barmherzige Brüder Wien, Vienna

1036

RECRUITING

Obudai Egeszsegugyi Centrum Kft., Budapest

1088

RECRUITING

Semmelweis Egyetem, Budapest

1090

RECRUITING

Medizinische Universität Wien, Vienna

1136

RECRUITING

Pannonia Maganorvosi Centrum, Budapest

1200

RECRUITING

Cliniques Universitaires St-Luc, Brussels

2050

RECRUITING

Royal Prince Alfred Hospital, Sydney

2650

RECRUITING

UZ Antwerpen, Edegem

2730

RECRUITING

Herlev Hospital, Herlev

3076

RECRUITING

Northern Hospital, Epping

3100

RECRUITING

Universitätsklinikum St. Pölten, Sankt Pölten

3200

RECRUITING

Clinexpert Gyongyos Kft, Gyöngyös

3500

RECRUITING

Jessa Zkh (Campus Virga Jesse), Hasselt

4000

RECRUITING

CHC MontLégia, Liège

RECRUITING

CHU de Liège (Sart Tilman), Liège

4101

RECRUITING

Mater Misericordiae Limited, South Brisbane

5100

RECRUITING

MHAT St. Ivan Rilski, Gorna Oryahovitsa

5112

RECRUITING

Lyell McEwin Hospital, Adelaide

5600

RECRUITING

Bekes Varmegyei Kozponti Korhaz, dr Rethy Pal Tagkorhaz, Békéscsaba

6020

RECRUITING

Medizinische Universität Innsbruck, Innsbruck

7000

RECRUITING

CHU HELORA - Hôpital de Mons - Site Kennedy, Mons

7100

RECRUITING

Clinfan Szolgaltato Kft., Szekszárd

8000

RECRUITING

Fejer Varmegyei Szent György Egyetemi Oktatokorhaz, Székesfehérvár

9000

RECRUITING

AZ Maria Middelares, Ghent

RECRUITING

AZ Sint Lucas (Sint Lucas), Ghent

9100

RECRUITING

Vitaz, Sint-Niklaas

9300

RECRUITING

AZORG Campus Aalst-Moorselbaan, Aalst

10075

RECRUITING

Lenox Hill Hospital, New York

10128

RECRUITING

Ospedale Mauriziano Umberto I, Turin

10134

RECRUITING

CEMDOE (Centro Médico de Diabetes, Obesidad y Especialidades), Santo Domingo

10330

RECRUITING

Division of Gastroenterology, Depart of Medicine, Fac of Med., Chulalongkorn University, Bangkok

10700

RECRUITING

Division of Gastroenterology, Depart of Internal Med, Siriraj H, Mahidol Uni, Bangkok

11001

RECRUITING

Clinica del Country, Bogotá

11040

RECRUITING

University Hospital Center Dr Dragisa Misovic - Dedinje, Belgrade

11120

RECRUITING

University Hospital Medical Center Zvezdara, Belgrade

11418

RECRUITING

Mainstreet - Richmond Hill Clinic, Richmond Hill

11428

RECRUITING

Queens Village Medical Care, Queens Village

11758

RECRUITING

DiGiovanna Inst for Med Ed&Res, North Massapequa

12120

RECRUITING

Thammasat University Hospital, Pathum Thani

12203

RECRUITING

Charite - Campus Benjamin Franklin, Berlin

13015

RECRUITING

Hopital Nord, Marseille

14618

RECRUITING

Gastroenterology Group Of Rochester, LLP, Rochester

20017

RECRUITING

ASST Rhodense - Ospedale di Rho, Rho

20176

RECRUITING

Emeritas Research Group, Lansdowne Town Center

23320

RECRUITING

Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater, Chesapeake

24014

RECRUITING

Gastroenterology Consultants and Endoscopy Center of Southwest Virginia, Roanoke

27526

RECRUITING

Omega Research North Carolina, LLC, Fuquay-Varina

28046

RECRUITING

Hospital Universitario La Paz, Madrid

28112

RECRUITING

Monroe Biomedical Research, Monroe

29425

RECRUITING

Medical University of South Carolina, Charleston

29607

RECRUITING

Gastroenterology Associates, PA PA of Greenville, Greenville

30003

RECRUITING

Hospital Universitario Reina Sofía, Murcia

30327

RECRUITING

Digestive Healthcare of Georgia, Atlanta

30342

RECRUITING

Atlanta Gastroenterology Associates, Atlanta

31000

RECRUITING

Borzan Polyclinic, Osijek

31201

RECRUITING

Gastroenterology Associates of Central Georgia, Macon

32806

RECRUITING

Orlando Regional Healthcare, Orlando

33013

RECRUITING

The Sister Life Research, Hialeah

33016

RECRUITING

NeoClinical Research, Hialeah

33126

RECRUITING

LCC Medical Research Institute, LLC, Miami

33134

RECRUITING

HealthMed Clinical Center Inc., Coral Gables

RECRUITING

Hi Tech and Global Research, LLC, Coral Gables

33176

RECRUITING

Ambert Medical Research, Miami

33604

RECRUITING

CHU Bordeaux - Hôpital Haut-Lévêque, Pessac

33607

RECRUITING

Nodal Medical Center Research - NMC, Tampa

33612

RECRUITING

University of South Florida School of Medicine Morsani Center for Advanced Health Care, Tampa

33614

RECRUITING

Guardian Angel Research Center, LLC, Tampa

33617

RECRUITING

Theia Clinical Research Centers, LLC, Temple Terrace

33756

RECRUITING

Gastro Florida, Clearwater

34211

RECRUITING

Florida Research Institute - Lakewood, Lakewood Rch

34613

RECRUITING

Access Research Institute, Brooksville

34741

RECRUITING

Clinical Research of Osceola, LLC, Kissimmee

35033

RECRUITING

CHU de Rennes - Hopital de Pontchaillo, Rennes

36305

RECRUITING

Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan, Dothan

37211

RECRUITING

Quality Medical Research, Nashville

38138

RECRUITING

Gastro One, Germantown

38655

RECRUITING

Gastroenterology Associates and Endoscopy Center of North Mississippi, Oxford

38671

RECRUITING

Delta Gastroenterology & Endoscopy Center, Southaven

39008

RECRUITING

Hospital Universitario Marques de Valdecilla, Santander

40002

RECRUITING

Khon Kaen Uni, Khon Kaen

40201

RECRUITING

Chung Shan Medical University Hospital, Taichung

40218

RECRUITING

Gastroenterology Health Partners, PLLC, Louisville

40447

RECRUITING

China Medical University Hospital, Taichung

42055

RECRUITING

CHU Saint Etienne - Hôpital Nord, Saint-Etienne

43202

RECRUITING

Ohio Gastroenterology Group, Columbus

43210

RECRUITING

The Ohio State University Wexner Medical Center, Columbus

44145

RECRUITING

Gastro Intestinal Research Institute of Northern Ohio, Westlake

44212

RECRUITING

Digestive Disease Consultants, Brunswick

44600

RECRUITING

Boca Clinical Trials Mexico S.C. (Guadalajara), Guadalajara

45440

RECRUITING

Dayton Gastroenterology, Inc., Beavercreek

46202

RECRUITING

Indiana University Health University Hospital, Indianapolis

47150

RECRUITING

Gastroenterology Health Partners, PLLC, New Albany

48334

RECRUITING

Michigan Center of Medical Research, Farmington Hills

48960

RECRUITING

Hospital de Galdakao, Galdacao

51092

RECRUITING

Hopital Robert Debre, Reims

60026

RECRUITING

Illinois Gastroenterology Group-Glenview powered by GI Alliance, Glenview

60031

RECRUITING

GI Alliance - Gurnee, Gurnee

60431

RECRUITING

AGAPLESION Markus-Krankenhaus, Frankfurt

60590

RECRUITING

Klinik Johann Wolfgang von Goethe Uni, Frankfurt

60611

RECRUITING

Northwestern Memorial Hospital, Chicago

67226

RECRUITING

Kansas Gastroenterology, LLC under Clinical Trials Network, Wichita

68167

RECRUITING

Klinikum Mannheim GmbH Universitätsklinikum, Mannheim

71013

RECRUITING

IRCCS Ospedale Casa Sollievo della Soffenza, San Giovanni Rotondo

73071

RECRUITING

Central Sooner Research, Norman

75149

RECRUITING

SMS Clinical Research, LLC, Mesquite

75701

RECRUITING

Tyler Research Institute, LLC, Tyler

76012

RECRUITING

Texas Clinical Research Institute, LLC, Arlington

76063

RECRUITING

TDDC dba GI Alliance Research, Mansfield

76092

RECRUITING

GI Alliance - Southlake, Southlake

76508

RECRUITING

Baylor Scott and White Medical Center, Temple

77430

RECRUITING

Universitaetsklinikum Jena, Jena

78229

RECRUITING

Gastroenterology Research of America, LLC, San Antonio

78550

RECRUITING

Cano Medical Center, Harlingen

78628

RECRUITING

Amel Med LLC, Georgetown

79902

RECRUITING

Proactive El Paso,LLC, El Paso

80054

RECRUITING

CHU Amiens - Hopital Sud, Amiens

80120

RECRUITING

Rocky Mountain Gastroenterology, Littleton

80124

RECRUITING

Peak Gastroenterology Surgery Center, Lone Tree

80131

RECRUITING

Universita'degli Studi di Napoli Federico II, Napoli

82445

RECRUITING

E-Da Hospital, Kaohsiung City

83404

RECRUITING

Grand Teton Research Group, PLLC, Idaho Falls

84101

RECRUITING

Soroka University Medical Centre, Beersheba

85351

RECRUITING

Arizona Digestive Health, P.C (ADH), Sun City

89030

RECRUITING

Las Vegas Clinical Trials, LLC, North Las Vegas

89081

RECRUITING

Universitätsklinikum Ulm, Ulm

90110

RECRUITING

Division of Gastroenterology, Depart of Medicine, Fac. of Med, Songklanagarind University, Songkhla

90301

RECRUITING

310 Clinical Research, Inglewood

90720

RECRUITING

United Gastroenterologists, Los Alamitos

92120

RECRUITING

Acclaim Clinical Research, Inc., San Diego

93534

RECRUITING

Gastro Care Associates, Lancaster

RECRUITING

Om Research LLC, Lancaster

94115

RECRUITING

UCSF/Medical Center at Mount Zion, San Francisco

97000

RECRUITING

Medical Care & Research SA de CV, Mérida

98664

RECRUITING

The Vancouver Clinic, Vancouver

100191

RECRUITING

Peking University Third Hospital, Beijing

130021

RECRUITING

the First Hospital of Jilin University, Changchun

200126

RECRUITING

Shanghai East Hospital, Shanghai

214023

RECRUITING

Wuxi People's Hospital, Wuxi

230001

RECRUITING

Anhui Provincial Hospital, Hefei

230022

RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

310006

RECRUITING

Zhejiang Province Traditional Chinese Medical Hospital, Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou

315000

RECRUITING

The First Affiliated Hospital of Ningbo University, Ningbo

318050

RECRUITING

Taizhou Hospital Of Zhejiang Province, Taizhou

330006

RECRUITING

The 1st Affiliated Hospital of Nanchang Unversity, Nanchang

350005

RECRUITING

The First Affiliated Hospital Of Fujian Medical University, Fuzhou

361004

RECRUITING

Zhongshan Hospital Xiamen University, Xiamen

401147

RECRUITING

Chongqing General Hospital, Chongqing

410013

RECRUITING

Third Xiangya Hospital Centrel South University, Changsha

412007

RECRUITING

Zhuzhou Central Hospital, Zhuzhou

430014

RECRUITING

The Central Hospital of Wuhan, Wuhan

430060

RECRUITING

Ren Min Hospital Affiliated Wu Han University, Wuhan

500003

RECRUITING

Yashoda Hospitals, Secunderabad

500032

RECRUITING

AIG Hospitals, Gachibowli

510260

RECRUITING

The second Affiliated Hospital of Guangzhou Medical University, Guangzhou

510655

RECRUITING

The sixth affiliated hospital of Sun Yat-Sen University, Guangzhou

516001

RECRUITING

Huizhou Central People's Hospital, Huizhou

518036

RECRUITING

Peking University Shenzhen Hospital, Shenzhen

530021

RECRUITING

The First Affiliate Hospital of Guangxi Medical University, Nanning

610041

RECRUITING

West China Hospital of Sichuan University, Chengdu

4030000

RECRUITING

Hospital Guillermo Grant Benavente, Concepción

5265601

RECRUITING

Chaim Sheba Medical Center, Ramat Gan

7500000

RECRUITING

Medwal, Santiago

92845-2006

RECRUITING

Valley View Internal Medicine, Garden Grove

41017-3409

RECRUITING

Tri-State Gastroenterology Associates, Crestview Hills

02115

RECRUITING

Brigham and Women's Hospital, Boston

15401-9069

RECRUITING

Frontier Clinical Re search, LLC, Uniontown

02904

RECRUITING

University Gastroenterology, Providence

23188-2862

RECRUITING

Tidewater Physicians Multispecialty Group (TPMG) - Clinical Research Division - Williamsburg, Williamsburg

C1280AEB

RECRUITING

Hospital Britanico, Ciudad Autonoma Bs As

70200-730

RECRUITING

L2 Ip Instituto de Pesquisas Clinicas Ltda ME, Brasília

80430-160

RECRUITING

Centro Digestivo de Curitiba, Curitiba

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre X, Porto Alegre

18618-970

RECRUITING

UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu, Botucatu

13060-904

RECRUITING

Centro de Pesquisa São Lucas, Campinas

01228-000

RECRUITING

CPQuali Pesquisa Clinica Ltda, São Paulo

03325-050

RECRUITING

BR Trials - Pesquisa Clínica, São Paulo

T6K 4B2

RECRUITING

South Edmonton Gastroenterology, Edmonton

G8T 7A1

RECRUITING

C.I.C. Mauricie, Trois-Rivières

Unknown

RECRUITING

Clinica Universidad de Los Andes, Santiago

RECRUITING

The Second Affiliated Hospital of Zhengzhou University, Zhengzhou

RECRUITING

Endo-Med Sp. z o.o., Karczew

050034

RECRUITING

Hospital Pablo Tobon Uribe, Medellín

602 00

RECRUITING

SurGal Clinic s.r.o., Brno

370 01

RECRUITING

Nemocnice Ceske Budejovice a.s., České Budějovice

500 02

RECRUITING

Gastroenterologie s.r.o., Hradec Králové

500 05

RECRUITING

Fakultni nemocnice Hradec Kralove, Hradec Králové

06202

RECRUITING

CHU Nice - Hopital de l'Archet 2, Nice

06120

RECRUITING

Universitaetsklinikum Halle (Saale), Halle

01010

RECRUITING

Celan S.A., Guatemala City

01016

RECRUITING

Medi-k, Guatemala City

00186

RECRUITING

Ospedale Isola Tiberina Gemelli, Rome

09042

RECRUITING

Azienda Ospedaliero - Universitaria di Cagliari, Monserrato

078-8510

RECRUITING

Asahikawa Medical University Hospital, Asahikawa-shi

760-0017

RECRUITING

Takamatsu Red Cross Hospital, Takamatsu

981-3213

RECRUITING

Takagi clinic, Sendai

443-8501

RECRUITING

Gamagori City Hospital, Aichi

070-8610

RECRUITING

Asahikawa City Hospital, Asahikawa-shi

277-0871

RECRUITING

Tsujinaka Hospital Kashiwanoha, Chiba

818-8502

RECRUITING

Fukuoka University Chikushi Hospital, Chikushino-shi

910-8526

RECRUITING

Fukui Prefectural Hospital, Fukui

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center, Fukuoka

734-8530

RECRUITING

Hiroshima Prefectural Hospital, Hiroshima

734-8551

RECRUITING

Hiroshima University Hospital, Hiroshima

060-8543

RECRUITING

Sapporo Medical University Hospital, Hokkaido

920-8530

RECRUITING

Ishikawa Prefectural Central Hospital, Ishikawa

760-8557

RECRUITING

Kagawa Prefectural Central Hospital, Kagawa

892-0846

RECRUITING

Sameshima Hospital, Kagoshima

861-8520

RECRUITING

Japanese Red Cross Kumamoto Hospital, Kumamoto

530-0011

RECRUITING

Kinshukai Infusion Clinic, Osaka

540-0006

RECRUITING

National Hospital Organization Osaka National Hospital, Osaka

840-8571

RECRUITING

Saga-ken Medical Centre Koseikan, Saga

849-8501

RECRUITING

Saga University Hospital, Saga

411-8611

RECRUITING

National Hospital Organization Shizuoka Medical Center, Shizuoka

432-8061

RECRUITING

Matsuda Hospital, Shizuoka

113-8519

RECRUITING

Institute of Science Tokyo Hospital, Tokyo

169-0073

RECRUITING

JCHO Tokyo Yamate Medical Center, Tokyo

640-8558

RECRUITING

Japanese Red Cross Wakayama Medical Center, Wakayama

990-9585

RECRUITING

Yamagata University Hospital, Yamagata

400-8506

RECRUITING

Yamanashi Prefectural Central Hospital, Yamanashi

06726

RECRUITING

Hospital General de Mexico, Mexico

5022 GC

RECRUITING

ETZ Elisabeth, Tilburg

3584 CX

RECRUITING

Universitair Medisch Centrum Utrecht, Utrecht

92-213

RECRUITING

Clinical Trials UMED Sp. z o. o., ?ód?

85-229

RECRUITING

"Centrum Medyczne Medis", Bydgoszcz

89-600

RECRUITING

Centrum Medyczne Lukamed Joanna Luka-Wendrowska, Chojnice

34-400

RECRUITING

Allmedica Badania Kliniczne Sp z o.o. Sp K., Nowy Targ

95-200

RECRUITING

NZOZ Eskulap Pabianice, Pabianice

60-529

RECRUITING

SOLUMED Centrum Medyczne, Późna

35-055

RECRUITING

"Centrum Medyczne MEDYK", Rzeszów

87-100

RECRUITING

Gastromed Sp. z o.o., Toru?

00-728

RECRUITING

WIP Warsaw IBD Point Profesor Kierkus, Warsaw

02-507

RECRUITING

Centralny Szpital Kliniczny MSW w Warszawie, Warsaw

50-220

RECRUITING

Przychodnia EuroMediCare, Wroc?aw

50-449

RECRUITING

Melita Medical, Wroc?aw

53-149

RECRUITING

Vistamed & Vertigo Spó?Ka Z Ograniczon? Odpowiedzialno?Ci?, Wroc?aw

22-400

RECRUITING

ETG Zamosc, Zamość

4710-243

RECRUITING

Hospital de Braga, Braga

1649-035

RECRUITING

Hospital de Santa Maria, Lisbon

4202-451

RECRUITING

Hospital de Sao Joao, Porto

4520-211

RECRUITING

Centro Hospitalar de Entre Douro e Vouga - H. São Sebastião, Santa Maria da Feira

3504-509

RECRUITING

Hospital Sao Teotonio, Viseu

00909

RECRUITING

Klinical Investigations Group LLC, San Juan

HA1 3UJ

RECRUITING

St Mark's Hospital & Imperial College, Harrow

L7 8XP

RECRUITING

Royal Liverpool University Hospital, Liverpool

SE5 9RS

RECRUITING

King College Hospital NHS Foundation Trust, London

W1T 6AH

RECRUITING

Queen Anne Street Medical Centre, London

NE1 4LP

RECRUITING

Royal Victoria Infirmary, Newcastle upon Tyne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY