Contribution of Bone to Urine Citrate

Instructed diet (400 mg Ca, 800 mg P, 100 mEq Na) and two liters of distilled water daily for three days (equilibration period), followed by a constant standardized meal with the same composition of Ca, P, and Na for one day. After 240hr urine sample collection patient fasted the preceding evening except for 300 ml of distilled water at 9 pm and 11 pm. On test days, 600 ml distilled water given and fasting blood obtained.

Potassium citrate load of 40meq will be given after fasting blood has been obtained

Zoledronic acid or Denosumab (as prescribed by their physician)

Romosozumab (as prescribed by their physician)