876
Participants
Start Date
January 1, 2025
Primary Completion Date
June 30, 2026
Study Completion Date
December 31, 2026
HVA
Homoharringtonine (HHT) is given by venous drip daily at 1 mg/m2 from day 1 to 7. Venetoclax (VEN) is given 100 mg on day 1, 200 mg on day 2, and 400 mg orally from day 3 to day 14. Azacitidine (AZA) is given 75 mg/m2 subcutaneously from day 1 to 7.
VA
VEN is given 100 mg on day 1, 200 mg on day 2, and 400 mg orally from day 3 to day 28, and AZA (75 mg/m2) is given subcutaneously from day 1 to 7.
Standard Chemotherapy
Standard Chemotherapy includes IA(Idarubicin combined with Cytarabine) or DA(Daunorubicin combined with Cytarabine). IDA is given by venous drip daily at 12mg/m2, or DNR is given by venous drip daily at 60mg/m2, from day 1-3, combined with Ara-C at 100mg/m2 by continuously venous drip from day 1-7.
RECRUITING
Department of Hematology,Nanfang Hospital, Southern Medical University, Guangzhou
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER
Guangzhou First People's Hospital
OTHER
Guangdong Second Provincial General Hospital
OTHER
Jiangmen Central Hospital
OTHER
Shenzhen Second People's Hospital
OTHER
First Affiliated Hospital of Guangxi Medical University
OTHER
Dongguan People's Hospital
OTHER_GOV
First People's Hospital of Foshan
OTHER
Guangdong Provincial Hospital of Traditional Chinese Medicine
OTHER
Huizhou Municipal Central Hospital
OTHER
Shenzhen Hospital of Southern Medical University
OTHER
Affiliated Hospital of Guangdong Medical University
OTHER
People's Hospital of Guangxi Zhuang Autonomous Region
OTHER
First People's Hospital of Chenzhou
OTHER
Hunan Provincial People's Hospital
OTHER
Ganzhou City People's Hospital
OTHER
First Affiliated Hospital of Gannan Medical University
OTHER
Nanfang Hospital, Southern Medical University
OTHER