A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

March 5, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

March 30, 2029

Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG

Obinutuzumab

Participants will receive intravenous (IV) obinutuzumab 7 days prior to the first dose of glofitamab.

DRUG

Glofitamab

Participants will receive IV glofitamab, both in combination with gemcitabine and oxaliplatin and as monotherapy, for up to 12 cycles (cycle length = 21 days).

DRUG

Gemcitabine

Participants will receive IV gemcitabine in combination with glofitamab and oxaliplatin for up to 8 cycles (cycles length = 21 days).

DRUG

Oxaliplatin

Participants will receive IV oxaliplatin in combination with glofitamab and gemcitabine for up to 8 cycles (cycle length = 21 days).

Trial Locations (48)

3002

RECRUITING

Epworth Hospital, East Melbourne

12200

RECRUITING

CAMPUS BENJAMIN FRANKLIN CharitéCentrum 14 Med.Klinik f.Hämatologie u.Onkologie, Berlin

12206

RECRUITING

New York Oncology Hematology, P.C., Albany

13057

RECRUITING

Hematology Oncology Associates of Central New York, East Syracuse

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20141

RECRUITING

Irccs Istituto Europeo Di Oncologia (IEO), Milan

20155

RECRUITING

Virginia Cancer Specialists, PC, Gainesville

23456

RECRUITING

Virginia Oncology Associates - Virginia Beach, Virginia Beach

25123

RECRUITING

A.O. Spedali Civili Di Brescia-P.O. Spedali Civili, Brescia

32608

RECRUITING

North Florida/ South Georgia VA Medical Center, Gainesville

32806

RECRUITING

Orlando Health Cancer Institute, Orlando

33140

RECRUITING

Mount Sinai Comprehensive Cancer Center, Miami

33600

RECRUITING

CHU de Bordeaux, Pessac

34295

RECRUITING

Chu de Montpellier-St Eloi, Montpellier

35033

RECRUITING

CHU DE RENNES - CHU Pontchaillou, Rennes

37000

RECRUITING

Chu De Tours, Tours

37203

RECRUITING

Tennessee Oncology, Nashville

37403

RECRUITING

Tennessee Oncology, Chattanooga

38700

RECRUITING

CHU de Grenoble, La Tronche

39120

RECRUITING

Otto von Guericke Uni Magdeburg Uniklinik, Magdeburg

40536

RECRUITING

University of Kentucky - Markey Cancer Center, Lexington

47014

RECRUITING

"IRCCS Istituto Romagnolo per lo studio dei tumori Dino Amadori", Meldola

50937

RECRUITING

Universitätsklinikum Köln, Cologne

62226

RECRUITING

Cancer Care Specialists of Central Illinois, Swansea

68130

RECRUITING

Nebraska Cancer Specialists, Omaha

70809

RECRUITING

Mary Bird Perkins Cancer Ctr, Baton Rouge

75702

RECRUITING

Texas Oncology- Northeast Texas, Tyler

76502

RECRUITING

Baylor Scott & White Health, Temple

77380

RECRUITING

Texas Oncology - Gulf Coast, The Woodlands

80012

RECRUITING

Rocky Mountain Cancer Centers, LLP, Aurora

80131

RECRUITING

Istituto Nazionale Tumori Irccs Fondazione g. Pascale, Napoli

83712

RECRUITING

St Luke?s Cancer Institute, Boise

90067

RECRUITING

Valkyrie Clinical Trials, Los Angeles

91204

RECRUITING

Los Angeles Cancer Network, Glendale

92835

RECRUITING

Providence Medical Foundation, Fullerton

94110

RECRUITING

Zuckerberg San Francisco General Hospital, San Francisco

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence St. Vincent Medical Center, Portland

97401

RECRUITING

Oncology Associates of Oregon, P.C, Eugene

98405

RECRUITING

Northwest Medical Specialties, Tacoma

99508

RECRUITING

Alaska Oncology & Hematology, LLC, Anchorage

90502-2006

RECRUITING

The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente, Torrance

02118

RECRUITING

Boston Medical Center, Boston

T2N 5G2

RECRUITING

Arthur J.E. Child Comprehensive Cancer Center, Calgary

R3E 0V9

RECRUITING

CancerCare Manitoba (CCMB), Winnipeg

463-707

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

03080

RECRUITING

Seoul National University Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY