A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

October 8, 2025

Primary Completion Date

March 18, 2027

Study Completion Date

May 8, 2027

Conditions
Major Depressive Disorder (MDD)Depression in AdultsDepression - Major Depressive DisorderDepression DisordersDepression DisorderDepression
Interventions
DRUG

CYB003

CYB003 is a deuterated psilocin analog.

BEHAVIORAL

Psychological Support

Manualized psychological support performed by facilitator.

Trial Locations (45)

2050

Royal Prince Alfred Hospital, Camperdown

3004

Ramsay Clinic, Melbourne

3053

Neurocentrix Research, Melbourne

3168

Monash University - Notting Hill, Notting Hill

4558

Thompson Brain & Mind Healthcare (TBMH), Maroochydore

10032

New York State Psychiatric Institute, New York

11528

Eginitio Hospital, Athens

12462

Attikon University Hospital, Athens

19104

Adams Clinical Philadelphia, Philadelphia

30060

Psych Atlanta, Marietta

30329

Emory University Dept of Psychiatry and Behavioral Studies, Atlanta

32256

CNS Healthcare, Jacksonville

32751

Accel Research Sites - Maitland, Maitland

34105

Aqualane Clinical Research, Naples

35209

UAB Psychiatry and Behavioral Neurology, Birmingham

56404

Papageorgiou General Hospital, Thessaloniki

60612

Rush University, Chicago

70006

Tandem Clinical Research, Marrero

72204

Pillar Clinical Research - Little Rock, Little Rock

73112

SP Research PLLC, Oklahoma City

76104

North Texas Clinical Trials, Fort Worth

77046

Brain Health Consultants and TMS Center, Houston

78229

Clinical Trials of Texas, LLC, San Antonio

78737

Austin Clinical Trial Partners, Austin

90025

CalNeuro Research Group, Los Angeles

90404

Psychedelic Science Institute, Santa Monica

91206

Behavioral Research Specialists, LLC, Glendale

92251

Sun Valley Research Center, Imperial

92675

Inland Psychiatric Medical Group Inc (IPMG Research), San Juan Capistrano

92866

ATP Clinical Research, Orange

92868

NRC Research Institute, Orange

94305

Stanford University, Stanford

98104

Seattle Neuropsychiatric Treatment Center, Seattle

98201

Core Clinical Research, Everett

06511

Yale School of Medicine - Connecticut Mental Health Center (CMHC), New Haven

08755

Bio Behavioral Health, Toms River

D24 WK80

Sheaf House - Tallaght Adult Mental Health Service, Dublin

H91 VE03

La Nua Day Hospital Mental Health Centre, Galway

RG7 8PA

Ascend Clinical Research, Reading

DN2 5LT

Clerkenwell Health - Doncaster, Doncaster

G51 4TF

Queen Elizabeth University Hospital, Glasgow

SE5 9RS

King's College London, London

W1G 8DR

Clerkenwell Health - Welbeck Street, London

W1U 6RP

Clerkenwell Health - Baker Street, London

NE4 6BE

Wolfson Unit - Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Worldwide Clinical Trials

OTHER

lead

Cybin IRL Limited

INDUSTRY