Efficacy and Safety of Renal Denervation on Isolated Diastolic Hypertension

Renal denervation performed using the Symplicity Spyral™ multi-electrode renal denervation system, which is approved for interventional treatment of hypertension. This procedure involves catheter-based radiofrequency ablation of the renal nerves to reduce sympathetic activity and lower blood pressure.

A sham procedure involving renal angiography without the application of radiofrequency energy. This control intervention is used to maintain blinding.