Clinical and Laboratory Profile of Myasthenia Gravis in Children At Sohag University Hospitals

"Thorough clinical examination:~1\. General examination including general look, vital signs and anthropometric measurements.~2\. Scale system include gross motor function and muscle power(Quantitative Myasthenia Gravis Scale) \[36\] 3. detailed neurological examination including motor ,sensory and reflexes. (C) Investigations:~1. Electrophysiological testing:~ EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes.~ NCS: including repetitive nerve stimulation test (r NST)~2. laboratory studies:~ * Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.~ * Thyroid function tests :~3. Imaging:~ • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.~4. molecular studies (when possible)."

"C) Investigations:~1. Electrophysiological testing:~ EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes.~ NCS: including repetitive nerve stimulation test (r NST)~2. laboratory studies:~ * Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.~ * Thyroid function tests :~3. Imaging:~ • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.~4. molecular studies (when possible)."