A Response Surface Analysis for the Interaction Between Ciprofol and Sevoflurane

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

February 1, 2025

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Induction of General Anesthesia
Interventions
DRUG

Sevoflurane 0 + different doses of ciprofol

Sevoflurane 0% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.6mg/kg, respectively.

DRUG

Sevoflurane 0.7% + different doses of ciprofol

Sevoflurane 0.7% combined with ciprofol 0.1, 0.2, 0.3, 0.4, 0.5mg/kg, respectively.

DRUG

Sevoflurane 1.0% + different doses of ciprofol 0.05

Sevoflurane 1.0% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.

DRUG

Sevoflurane 1.5% + differnet doses of ciprofol

Sevoflurane 1.5% combined with ciprofol 0.05, 0.1, 0.2, 0.3, 0.4mg/kg, respectively.

DRUG

Sevoflurane 2.0% + different doses of ciprofol

Sevoflurane 2.0% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.

DRUG

Sevoflurane 2.5% + different doses of ciprofol

Sevoflurane 2.5% combined with ciprofol 0.05, 0.1, 0.15, 0.2, 0.3mg/kg, respectively.

DRUG

Ciprofol 0 + different end-expiratory concentration of sevoflurane

Ciprofol 0 combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5%, respectively.

DRUG

Ciprofol 0.05mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.05 mg/kg combined with sevoflurane 0.7, 1.5, 2.0, 2.5, 3.5 %, respectively.

DRUG

Ciprofol 0.1mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.1mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.

DRUG

Ciprofol 0.2 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.2 mg/kg combined with sevoflurane 0.5, 1.5, 2.0, 2.5, 3.0 %, respectively.

DRUG

Ciprofol 0.3 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.3 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.

DRUG

Ciprofol 0.4 mg/kg + different end-expiratory concentration of sevoflurane

Ciprofol 0.4 mg/kg combined with sevoflurane 0.5, 1.0, 1.5, 2.0, 2.5 %, respectively.

All Listed Sponsors
collaborator

Sichuan Provincial People's Hospital

OTHER

lead

Feng Gao

OTHER