Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

PHASE4RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

January 15, 2025

Primary Completion Date

June 1, 2025

Study Completion Date

July 1, 2025

Conditions
Post-induction HypotensionLidocaineOpioidEmergency Laparotomy
Interventions
DRUG

Lidocaine

After preoxygenation with 100% oxygen for 3 minutes, the study drug (lidocaine) will be administered. Patients will receive 1 mg/kg lidocaine of 10 mg/mL lidocaine solution (prepared by diluting 5 mL of lidocaine 20% in saline to a total volume of 10 mL)

DRUG

Fentanyl

After preoxygenation with 100% oxygen for 3 minutes, the study drug (fentanyl) will be administered. Patients will receive 1 mcg/kg fentanyl of 10 mcg/mL fentanyl solution (prepared by diluting 100 mcg fentanyl in saline to a total volume of 10 mL).

DRUG

Propofol

After administration of the study drug, all patients will receive 2 mg/kg propofol intravenously

DRUG

Succinyl choline

After loss of consciousness, 1 mg/kg succinyl choline will be administered over 5 seconds, and tracheal intubation will be done through direct laryngoscopy after 60 seconds.

Trial Locations (1)

Unknown

RECRUITING

Faculty of Medicine, Cairo University, Cairo

All Listed Sponsors
lead

Cairo University

OTHER