Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

June 3, 2025

Primary Completion Date

February 1, 2032

Study Completion Date

February 1, 2032

Conditions
Non-Muscle Invasive Bladder Urothelial CarcinomaRecurrent Non-Muscle Invasive Bladder Urothelial CarcinomaStage I Bladder Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and urine sample collection

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Fluorouracil

Given IV

DRUG

Gemcitabine

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Mitomycin

Given IV

BIOLOGICAL

Pembrolizumab

Given IV

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radiation Therapy

Undergo radiation therapy

Trial Locations (79)

15146

RECRUITING

UPMC Cancer Center - Monroeville, Monroeville

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15301

RECRUITING

UPMC Cancer Center-Washington, Washington

RECRUITING

UPMC Washington Hospital Radiation Oncology, Washington

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16105

RECRUITING

UPMC Hillman Cancer Center - New Castle, New Castle

16121

RECRUITING

UPMC Cancer Center at UPMC Horizon, Farrell

16346

RECRUITING

UPMC Cancer Center at UPMC Northwest, Seneca

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

17837

RECRUITING

Geisinger Medical Oncology-Lewisburg, Lewisburg

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19317

RECRUITING

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

23114

RECRUITING

Bon Secours Saint Francis Medical Center, Midlothian

23116

RECRUITING

Bon Secours Memorial Regional Medical Center, Mechanicsville

23226

RECRUITING

Bon Secours Saint Mary's Hospital, Richmond

23230

RECRUITING

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23970

RECRUITING

VCU Community Memorial Health Center, South Hill

26506

RECRUITING

West Virginia University Healthcare, Morgantown

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

30303

RECRUITING

Grady Health System, Atlanta

30308

RECRUITING

Emory Proton Therapy Center, Atlanta

RECRUITING

Emory University Hospital Midtown, Atlanta

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

RECRUITING

Emory Saint Joseph's Hospital, Atlanta

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

54806

RECRUITING

Duluth Clinic Ashland, Ashland

RECRUITING

Northwest Wisconsin Cancer Center, Ashland

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

RECRUITING

Essentia Health Saint Mary's Medical Center, Duluth

RECRUITING

Miller-Dwan Hospital, Duluth

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

60612

RECRUITING

Rush MD Anderson Cancer Center, Chicago

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

RECRUITING

Mercy Hospital South, St Louis

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

65065

RECRUITING

Lake Regional Hospital, Osage Beach

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

70002

RECRUITING

Mary Bird Perkins Cancer Center - Metairie, Metairie

70737

RECRUITING

Mary Bird Perkins Cancer Center - Gonzales, Gonzales

70809

RECRUITING

Louisiana Hematology Oncology Associates LLC, Baton Rouge

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

81632

RECRUITING

Shaw Cancer Center, Edwards

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

93301

RECRUITING

AIS Cancer Center at San Joaquin Community Hospital, Bakersfield

17033-0850

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH