The FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour

NANot yet recruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

March 10, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Childhood Brain TumorChildhood Brain TumorsPediatric Brain NeoplasmsPediatric Brain Tumor
Interventions
BEHAVIORAL

THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Full intervention

A novel strategy-based cognitive rehabilitation intervention that can be delivered with or without cognitive fatigue management. Skills are targeted sequentially based on a developmental hierarchical model where cognitive fatigue can be addressed first, followed by adult-supported compensatory strategies, with independent use of strategies for specific impairments delivered only once these earlier levels have been addressed. The 'FLaME' program incorporates strategies that have been trialled and found successful in fatigue (e.g., pacing and activity scheduling) and cognitive rehabilitation (e.g., chunking, elaborative encoding techniques) interventions for children. The intervention address two key issues: 1) to deliver strategy-based cognitive rehabilitation as an alternative to prevailing drill-based approaches, and 2) to integrate fatigue management to improve feasibility and acceptability of cognitive rehabilitation. This arm include the full intervention.

BEHAVIORAL

THE FATIGUE, LEARNING, AND MEMORY ENRICHMENT (FLaME) INTERVENTION - Cognitive rehabilitation only

A novel strategy-based cognitive rehabilitation intervention that can be delivered with or without cognitive fatigue management. Skills are targeted sequentially based on a developmental hierarchical model where cognitive fatigue can be addressed first, followed by adult-supported compensatory strategies, with independent use of strategies for specific impairments delivered only once these earlier levels have been addressed. The 'FLaME' program incorporates strategies that have been trialled and found successful in fatigue (e.g., pacing and activity scheduling) and cognitive rehabilitation (e.g., chunking, elaborative encoding techniques) interventions for children. The intervention address two key issues: 1) to deliver strategy-based cognitive rehabilitation as an alternative to prevailing drill-based approaches, and 2) to integrate fatigue management to improve feasibility and acceptability of cognitive rehabilitation. This arm includes the cognitive rehabilitation only.

Trial Locations (1)

WC1N 3JH

Great Ormond Street Hospital for Children, London

All Listed Sponsors
collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

Success Charity

UNKNOWN

collaborator

Child Brain Injury Trust

UNKNOWN

collaborator

Cambridge University Hospitals NHS Foundation Trust

OTHER

collaborator

The UCL Great Ormond Street Institute of Child Health

OTHER

collaborator

Nottingham University Hospitals NHS Trust

OTHER

lead

Great Ormond Street Hospital for Children NHS Foundation Trust

OTHER

NCT06770335 - The FLaME Cognitive Rehabilitation Study for Childhood Brain Tumour | Biotech Hunter | Biotech Hunter