60
Participants
Start Date
February 28, 2025
Primary Completion Date
January 31, 2027
Study Completion Date
January 31, 2028
First-line Immunotherapy Combined with Chemoradiotherapy for ES-SCLC
"Cohort 1:~Induction Phase: Patients will receive three cycles of atezolizumab in combination with carboplatin/cisplatin plus etoposide.~Concurrent Radiotherapy Phase: the fourth cycle will incorporate concurrent radiotherapy along with atezolizumab and chemotherapy.~Maintenance Phase: Atezolizumab monotherapy will be administered until disease progression or intolerance by the patient, with atezolizumab being administered for a maximum duration of 2 years.~Cohort 2:~Induction Phase: Patients will receive three cycles of atezolizumab in combination with carboplatin/cisplatin plus etoposide.~Sequential Radiotherapy Phase: the fourth cycle will receive sequential radiotherapy in combination with atezolizumab.Final,Atezolizumab monotherapy will be continued until disease progression."
Peking University Cancer Hospital and Institute, Beijing
Peking University Cancer Hospital & Institute
OTHER