Assessment of Adebelizumab Combined with Chemotherapy in Concurrent Radiotherapy Versus Sequential Radiotherapy As First-Line Treatment for Extensive-Stage Small Cell Lung Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 28, 2025

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2028

Conditions
SCLC, Extensive StageImmunotherapyChemotherapyRadiotherapy
Interventions
DRUG

First-line Immunotherapy Combined with Chemoradiotherapy for ES-SCLC

"Cohort 1:~Induction Phase: Patients will receive three cycles of atezolizumab in combination with carboplatin/cisplatin plus etoposide.~Concurrent Radiotherapy Phase: the fourth cycle will incorporate concurrent radiotherapy along with atezolizumab and chemotherapy.~Maintenance Phase: Atezolizumab monotherapy will be administered until disease progression or intolerance by the patient, with atezolizumab being administered for a maximum duration of 2 years.~Cohort 2:~Induction Phase: Patients will receive three cycles of atezolizumab in combination with carboplatin/cisplatin plus etoposide.~Sequential Radiotherapy Phase: the fourth cycle will receive sequential radiotherapy in combination with atezolizumab.Final,Atezolizumab monotherapy will be continued until disease progression."

Trial Locations (1)

100142

Peking University Cancer Hospital and Institute, Beijing

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER