Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

July 1, 2025

Study Completion Date

July 1, 2026

Conditions
Rectal CancerAdvanced Stage Colorectal CancerRadiotherapy
Interventions
DRUG

Adebrelimab Injection combined with radiotherapy and chemotherapy

"Radiotherapy regimen: SCRT short-term radiotherapy of 5 × 5Gy Immunotherapy regimen: Adebrelimab Injection 1200 mg or 20 mg/kg, iv., followed by administration on the 1st day of each subsequent chemotherapy cycle.~Chemotherapy regimen: CAPOX regimen (chemotherapy cycle d1, to chemotherapy cycle d14):~Oxaliplatin 130 mg/m2 iv d1~Capecitabine 1000 mg/m2 po bid d1\~14~Repeat every 3 weeks for 6 cycles~After completing 6 cycles of chemotherapy, the patient underwent TME surgery 2-3 weeks later."

Trial Locations (1)

250021

RECRUITING

Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan

All Listed Sponsors
lead

Feng Tian

OTHER_GOV