1,800
Participants
Start Date
January 3, 2025
Primary Completion Date
December 31, 2029
Study Completion Date
June 30, 2031
Blinatumomab (Group A)
For Group A I/HR-ALL patients after induction remission phase, continuous 28 days' blinatumomab followed by 3 cycles of high-dose methotrexate (HDMTX) will be applied, subsequently followed by interim continuation, late intensification, and maintenance therapy
Venetoclax (nonRand Group)
For I/HR patients non eligible for blinatumomab randomization, venetoclax+ mini-hyperCVD will be applied after PVDL induction, subsequently followed by CAT as intensification, interim continuation, late intensification, and maintenance therapy
Blinatumomab (Group B)
For Group B I/HR-ALL patients after induction remission phase: a two 14-day cycles of blinatumomab, alternating with three cycles of HDMTX will be applied, subsequently followed interim continuation, late intensification, and maintenance therapy
RECRUITING
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin
NOT_YET_RECRUITING
Anhui Medical University Second Affiliated Hospital, Hefei
NOT_YET_RECRUITING
Anhui Provincial Children's Hospital, Hefei
NOT_YET_RECRUITING
Fujian Medical University Union Hospital, Fuzhou
NOT_YET_RECRUITING
Guangzhou Women and Children's Medical Center, Guangzhou
NOT_YET_RECRUITING
Nanfang Hospital, Southern Medical University, Guangzhou
NOT_YET_RECRUITING
The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning
NOT_YET_RECRUITING
The Affiliated Hospital of Guizhou Medical University, Guiyang
NOT_YET_RECRUITING
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
NOT_YET_RECRUITING
Wuhan Children's Hospital, Wuhan
NOT_YET_RECRUITING
Hunan Children's Hospital, Changsha
NOT_YET_RECRUITING
Xiangya Hospital Central South University, Changsha
NOT_YET_RECRUITING
Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing
NOT_YET_RECRUITING
Children's Hospital of Soochow University, Suzhou
NOT_YET_RECRUITING
Jiangxi Provincial Children's Hospital, Nanchang
NOT_YET_RECRUITING
Qilu Hospital of Shandong University, Jinan
NOT_YET_RECRUITING
Affiliated Hospital of Qingdao University, Qingdao
NOT_YET_RECRUITING
Xi'an Northwest Women and Children Hospital, Xi’an
NOT_YET_RECRUITING
West China Second University Hospital, Sichuan University, Chengdu
NOT_YET_RECRUITING
Chongqing Medical University Affiliated Children's Hospital, Chongqing
NOT_YET_RECRUITING
Children's Hospital of Fudan University, Shanghai
NOT_YET_RECRUITING
Shanghai Children's Hospital, Shanghai
NOT_YET_RECRUITING
Shanghai Children's Medical Cener, Shanghai Jiao Tong University School of Medicine, Shanghai
NOT_YET_RECRUITING
Shenzhen Children's Hospital, Shenzhen
NOT_YET_RECRUITING
Hong Kong Children's Hospital, Hong Kong
Institute of Hematology & Blood Diseases Hospital, China
OTHER