This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

PHASE3RecruitingINTERVENTIONAL
Enrollment

714

Participants

Timeline

Start Date

July 23, 2025

Primary Completion Date

September 5, 2028

Study Completion Date

March 1, 2029

Conditions
Non-Small Cell Lung CancerCarcinoma, Non-Small-Cell LungCarcinoma, Non-Small-Cell Lung (NSCLC)
Interventions
DRUG

Sigvotatug Vedotin

MMAE-Antibody Drug Conjugate targeting Integrin Beta-6

DRUG

Pembrolizumab

Anti-PD-(L)1

Trial Locations (152)

704

NOT_YET_RECRUITING

National Cheng Kung University Hospital, Tainan City

807

NOT_YET_RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1090

RECRUITING

UZ Brussel, Brussels

1330

NOT_YET_RECRUITING

MHAT for Women's Health Nadezhda, Sofia

1407

NOT_YET_RECRUITING

Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD, Sofia

2800

RECRUITING

AZ Sint-Maarten, Mechelen

2930

RECRUITING

Algemeen Ziekenhuis klina, Brasschaat

4500

NOT_YET_RECRUITING

MBAL Uni Hospital, Panagyurishte

4560

NOT_YET_RECRUITING

Nambour General Hospital, Nambour

4570

NOT_YET_RECRUITING

Gympie Hospital, Gympie

4575

NOT_YET_RECRUITING

Sunshine Coast University Hospital, Birtinya

8000

RECRUITING

Complex Oncology Center - Burgas, Burgas

10002

NOT_YET_RECRUITING

National Taiwan University Hospital, Taipei

10960

RECRUITING

Hematology Oncology Associates of Rockland, Nyack

11217

NOT_YET_RECRUITING

Taipei Veterans General Hospital, Taipei

11407

RECRUITING

Hospital Jerez de la Frontera, Jerez de la Frontera

13620

NOT_YET_RECRUITING

Seoul National University Bundang Hospital, Seongnam

13915

RECRUITING

Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille

16247

RECRUITING

The Catholic University Of Korea St. Vincent's Hospital, Suwon

20132

NOT_YET_RECRUITING

Ospedale San Raffaele, Milan

27893

RECRUITING

Carolina Cancer Research Center, Wilson

28040

NOT_YET_RECRUITING

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

29004

NOT_YET_RECRUITING

Hospital Quironsalud Malaga, Málaga

NOT_YET_RECRUITING

Hospital Quirón Málaga, Málaga

29107

NOT_YET_RECRUITING

Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper

31059

NOT_YET_RECRUITING

CHU de Toulouse - Hopital Larrey, Toulouse

32763

RECRUITING

Mid Florida Hematology and Oncology Center, Orange City

33322

RECRUITING

BRCR Global, Plantation

33604

RECRUITING

CHU Bordeaux Haut-Leveque, Pessac

34070

NOT_YET_RECRUITING

Centre de Cancérologie du Grand Montpellier, Montpellier

39202

RECRUITING

Jackson Oncology Associates, PLLC, Jackson

39216

RECRUITING

Jackson Oncology Associates, PLLC, Jackson

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

41110

NOT_YET_RECRUITING

University General Hospital of Larissa, Larissa

41404

NOT_YET_RECRUITING

Kyungpook National University Chilgok Hospital, Deagu

44805

NOT_YET_RECRUITING

Institut de Cancérologie de l'Ouest, Saint-Herblain

46010

NOT_YET_RECRUITING

Hospital Clinico de Valencia, Valencia

47014

NOT_YET_RECRUITING

"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola

49241

RECRUITING

Pusan National University Hospital, Busan

49325

NOT_YET_RECRUITING

Centre Hospitalier de Cholet, Cholet

55101

RECRUITING

Regions Hospital, Saint Paul

55109

RECRUITING

M Health Fairview St. John's Hospital, Maplewood

RECRUITING

Minnesota Oncology Hematology PA, Maplewood

55125

RECRUITING

Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center, Woodbury

55337

RECRUITING

Minnesota Oncology Hematology, PA, Burnsville

55369

RECRUITING

Minnesota Oncology Hematology PA, Maple Grove

55404

RECRUITING

Minnesota Oncology Hematology PA, Minneapolis

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55422

RECRUITING

North Memorial Health Cancer Center, Robbinsdale

55426

RECRUITING

Park Nicollet Frauenshuh Cancer Center, Saint Louis Park

55432

RECRUITING

Minnesota Oncology Hematology PA, Fridley

55433

RECRUITING

Minnesota Oncology Hematology PA, Coon Rapids

55435

RECRUITING

M Health Fairview Cancer Clinic-Edina, Edina

RECRUITING

Minnesota Oncology Hematology PA, Edina

58128

RECRUITING

Chonnam National University Hwasun Hospital, Hwasun-gun

60451

RECRUITING

Hope and Healing Cancer Services, New Lenox

60521

RECRUITING

Hope and Healing Cancer Services, Hinsdale

68025

RECRUITING

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont, Fremont

68114

RECRUITING

Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist, Omaha

68124

RECRUITING

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan, Omaha

68130

RECRUITING

Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha

68516

RECRUITING

Cancer Partners of Nebraska - April Sampson Cancer Center, Lincoln

68803

RECRUITING

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island, Grand Island

RECRUITING

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional, Grand Island

73657

NOT_YET_RECRUITING

Chi Mei Hospital - Liouying Branch, Tainan City

73730

RECRUITING

Klinikum Esslingen, Esslingen am Neckar

75248

RECRUITING

Institut Curie, Paris

77030

NOT_YET_RECRUITING

The University of Texas MD Anderson Cancer Center Diagnostic Imaging, Houston

NOT_YET_RECRUITING

The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston

NOT_YET_RECRUITING

The University of Texas, MD Anderson Cancer Center- Interventional Radiology, Houston

NOT_YET_RECRUITING

University of Texas MD Anderson Cancer Center, Houston

77054

NOT_YET_RECRUITING

The University of Texas MD Anderson Cancer Center Clinical Research Imaging, Houston

77079

NOT_YET_RECRUITING

The University of Texas, MD Anderson Cancer Center - West Houston, Houston

77339

NOT_YET_RECRUITING

Community Clinical Trials, Kingwood

77380

RECRUITING

Renovatio Clinical, The Woodlands

77381

RECRUITING

Woodlands Radiology, The Woodlands

77384

NOT_YET_RECRUITING

The University of Texas, MD Anderson Cancer Center - Woodlands, Conroe

77478

NOT_YET_RECRUITING

The University of Texas, MD Anderson Cancer Center - Sugar Land, Sugar Land

77573

NOT_YET_RECRUITING

The University of Texas, MD Anderson Cancer Center - League City, League City

79915

RECRUITING

Renovatio Clinical - El Paso, El Paso

80131

NOT_YET_RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli

80401

RECRUITING

Intermountain Health Lutheran Hospital, Golden

RECRUITING

Lutheran Hospital - Cancer Centers of Colorado, Golden

81501

RECRUITING

Cancer Centers of Colorado St. Mary's Regional Hospital, Grand Junction

RECRUITING

Intermountain Health St. Mary's Regional Hospital, Grand Junction

81505

RECRUITING

Intermountain Health, Grand Junction

83100

NOT_YET_RECRUITING

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon

NOT_YET_RECRUITING

Azienda Ospedaliera San Giuseppe Moscati, Avellino

92835

RECRUITING

Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center, Fullerton

RECRUITING

Providence St. Jude Medical Center, Fullerton

RECRUITING

St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test), Fullerton

94010

NOT_YET_RECRUITING

Centre Hospitalier Intercommunal de Créteil, Créteil

100142

NOT_YET_RECRUITING

Beijing Cancer hospital, Beijing

101149

NOT_YET_RECRUITING

Beijing Chest Hospital,Capital Medical University, Beijing

200030

NOT_YET_RECRUITING

Shanghai Chest Hospital, Shanghai

221006

NOT_YET_RECRUITING

The Affiliated Hospital of Xuzhou Medical College, Xuzhou

250013

NOT_YET_RECRUITING

Jinan Central Hospital, Jinan

317000

NOT_YET_RECRUITING

Taizhou Hospital of Zhejiang Province, Taizhou

325000

NOT_YET_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330006

NOT_YET_RECRUITING

The First Affiliated Hospital of Nanchang University, Nanchang

430022

NOT_YET_RECRUITING

Wuhan Union Hospital Cancer Center, Wuhan

450008

NOT_YET_RECRUITING

Henan Cancer Hospital, Zhengzhou

516001

RECRUITING

Huizhou Central People's Hospital, Huizhou

833401

NOT_YET_RECRUITING

Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung City

2418515

NOT_YET_RECRUITING

Kanagawa cancer center, Yokohama

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

9013102

NOT_YET_RECRUITING

Shaare Zedek Medical Center, Jerusalem

9810914

NOT_YET_RECRUITING

Sendai Kousei Hospital, Sendai

04102

RECRUITING

Maine Medical Center, Portland

04074

RECRUITING

MaineHealth Cancer Care - Scarborough, Scarborough

04106

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

C1426ABP

NOT_YET_RECRUITING

Fundación Respirar, Ciudad Autónoma de Buenos Aires

140 59

RECRUITING

Fakultni Thomayerova nemocnice, Prague

741 01

RECRUITING

Nemocnice AGEL Novy Jicin a.s., Nový Jičín

115 27

NOT_YET_RECRUITING

"Thoracic General Hospital of Athens I Sotiria", Athens

155 62

RECRUITING

Metropolitan General Hospital, Athens

185 47

NOT_YET_RECRUITING

Metropolitan Hospital, Athens

151 23

NOT_YET_RECRUITING

Hygeia Hospital, Marousi

570 01

NOT_YET_RECRUITING

European Interbalkan Medical Center, Thessaloniki

115 26

RECRUITING

Errikos Dunant Hospital Center, Athens

552 36

NOT_YET_RECRUITING

Agios Loukas Clinic, Thessaloniki

00144

NOT_YET_RECRUITING

Istituto Nazionale Tumori Regina Elena, Rome

00186

NOT_YET_RECRUITING

Ospedale Isola Tiberina - Gemelli Isola, Rome

830-0011

NOT_YET_RECRUITING

Kurume University Hospital, Kurume

373-8550

NOT_YET_RECRUITING

Gunma Prefectural Cancer Center, Otashi

0708644

NOT_YET_RECRUITING

National Hospital Organization Asahikawa Medical Center, Asahikawa

650-0047

RECRUITING

Kobe City Medical Center General Hospital, Kobe

514-1101

RECRUITING

Mie Chuo Medical Center, Tsu

591-8555

NOT_YET_RECRUITING

NHO Kinki Chuo Chest Medical Center, Sakai

565-0871

NOT_YET_RECRUITING

The University of Osaka Hospital, Suita

113-8603

NOT_YET_RECRUITING

Nippon Medical School Hospital, Bunkyo-ku

104-0045

NOT_YET_RECRUITING

National Cancer Center Hospital, Chuo-ku

135-8550

NOT_YET_RECRUITING

The Cancer Institute Hospital of JFCR, Koto

152-8902

NOT_YET_RECRUITING

National Hospital Organization Tokyo Medical Center, Meguro-Ku

990-9585

RECRUITING

Yamagata University Hospital, Yamagata

810-8563

NOT_YET_RECRUITING

National Hospital Organization Kyushu Medical Center, Fukuoka

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

612-8555

RECRUITING

National Hospital Organization Kyoto Medical Center, Kyoto

701-1154

RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

541-8567

NOT_YET_RECRUITING

Osaka International Cancer Institute, Osaka

3844 DG

NOT_YET_RECRUITING

Ziekenhuis St. Jansdal, Harderwijk

3543 AZ

NOT_YET_RECRUITING

St. Antonius Ziekenhuis, locatie Utrecht, Utrecht

60-693

RECRUITING

Med-Polonia Sp. z o. o., Poznan

20-609

RECRUITING

Instytut Genetyki i Immunologii GENIM, Lublin

90-302

RECRUITING

Instytut MSF Sp zoo, Lodz

917 02

NOT_YET_RECRUITING

Fakultna nemocnica Trnava, Trnava

03722

RECRUITING

Severance Hospital, Yonsei University Health System, Seoul

07061

NOT_YET_RECRUITING

Boramae Medical Center, Seoul

03203

RECRUITING

Hospital General Universitario de Elche, Elche

08028

NOT_YET_RECRUITING

Hospital Universitari Dexeus, Barcelona

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY