Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

PHASE3RecruitingINTERVENTIONAL
Enrollment

674

Participants

Timeline

Start Date

June 30, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 30, 2028

Conditions
Breast Cancer
Interventions
DRUG

Arm A: Gedatolisib + Palbociclib or Ribociclib + Fulvestrant

"Drug: Gedatolisib Participants will receive intravenous (IV) gedatolisib once weekly for 3 weeks (Days 1, 8, 15) followed by 1 week off~Other Names:~• PF-05212384 Drug: Palbociclib Participants will receive oral palbociclib on days 1-21 of each 28-day cycle.~Other Names:~• IBRANCE Drug: Ribociclib Participants will receive oral ribociclib on Days 1-21 of each 28-day cycle~Other Names:~• KISQALI® Drug: Fulvestrant Participants will receive intramuscular (IM) fulvestrant every 2 weeks during Cycle 1 and then every 4 weeks~Other Names:~• Faslodex"

DRUG

Arm B: Palbociclib or Ribociclib + Fulvestrant

"Drug: Palbociclib Participants will receive oral palbociclib on Days 1-21 of each 28-day cycle~Other Names:~• IBRANCE Drug: Ribociclib Participants will receive oral ribociclib on Days 1-21 of each 28-day cycle~Other Names:~• KISQALI®~Drug: Fulvestrant Participants will receive intramuscular (IM) fulvestrant approximately every 2 weeks during Cycle 1 then approximately every 4~Other Names:~• Faslodex"

Trial Locations (188)

1200

NOT_YET_RECRUITING

Cliniques Universitaires Saint-Luc, Brussels

1330

NOT_YET_RECRUITING

MHAT Nadezhda - Medical Oncology Clinic, Sofia

1632

NOT_YET_RECRUITING

"MHAT Serdika EOOD, Base 2 - Second Department of Medical Oncology", Sofia

1756

NOT_YET_RECRUITING

USHAT of Oncology, Sofia

2076

NOT_YET_RECRUITING

Sydney Adventist Hospital, Wahroonga

2145

NOT_YET_RECRUITING

Westmead Hospital, Westmead

3000

NOT_YET_RECRUITING

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven

3500

NOT_YET_RECRUITING

Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie, Hasselt

4032

NOT_YET_RECRUITING

Debreceni Egyetem Klinikai Központ Nagyerdei Campus - Onkológiai Klinika, Debrecen

4215

NOT_YET_RECRUITING

Icon Cancer Centre Southport, Southport

4500

NOT_YET_RECRUITING

Multi-profile Hospital For Active Treatment-Uni Hospital Ltd., Panagyurishte

5000

NOT_YET_RECRUITING

GenesisCare - St Andrews, Adelaide

5700

NOT_YET_RECRUITING

Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaza, Gyula

6000

NOT_YET_RECRUITING

Bacs-Kiskun Varmegyei Oktatakorhaz, Kecskemét

6009

NOT_YET_RECRUITING

Breast Cancer Research Centre, Nedlands

6060

NOT_YET_RECRUITING

Grand Hopital De Charleroi, Charleroi

7002

NOT_YET_RECRUITING

Complex Oncological Centre Ruse, Rousse

7100

NOT_YET_RECRUITING

Tolna Varmegyei Balassa Janos Korhaz, Szekszárd

7624

NOT_YET_RECRUITING

Pecsi Tudomanyegyetem Klinikai Kozpont, Pécs

8000

NOT_YET_RECRUITING

Complex Oncology Center - Burgas, Burgas

9000

NOT_YET_RECRUITING

Universitair Ziekenhuis Gent - Medische Oncologie, Ghent

9024

NOT_YET_RECRUITING

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz, Győr

10002

NOT_YET_RECRUITING

Hospital San Pedro de Alcántara, Cáceres

10065

NOT_YET_RECRUITING

Weill Cornell Medical College - NewYork-Presbyterian Hospital, New York

10330

NOT_YET_RECRUITING

King Chulalongkorn Memorial Hospital [Medical Oncology], Bangkok

10400

NOT_YET_RECRUITING

Rajavithi Hospital, Bangkok

10700

NOT_YET_RECRUITING

Siriraj Hospital - Medical Oncology, Bangkok

11528

NOT_YET_RECRUITING

Areteio Hospital, Athens

11590

RECRUITING

Clinical Research Alliance, Inc., Westbury

13005

NOT_YET_RECRUITING

APHM Hopital Timone, Marseille

14467

NOT_YET_RECRUITING

University of Rochester Medical Center (URMC) - James P. Wilmot Cancer Center - Pluta Cancer Center (PCC), Rochester

15006

NOT_YET_RECRUITING

Complexo Hospitalario Universitario A Coruña, A Coruña

15706

NOT_YET_RECRUITING

Complejo Hospitalario Universitario De Santiago, Santiago de Compostela

16132

NOT_YET_RECRUITING

Ospedale San Martino IRCSS - Oncologia Medica 1, Genova

16150

NOT_YET_RECRUITING

Hospital Universiti Sains Malaysia, Kota Bharu

16499

NOT_YET_RECRUITING

Ajou University Hospital - Hematology/Oncology, Suwon

18547

NOT_YET_RECRUITING

Metropolitan Hospital, Piraeus

19004

NOT_YET_RECRUITING

Rittenhouse Hematology/Oncology, Philadelphia

20089

NOT_YET_RECRUITING

Istituto Clinico Humanitas, Rozzano

20141

NOT_YET_RECRUITING

IEO - Istituto Europeo di Oncologia, IRCCS, Milan

20230

NOT_YET_RECRUITING

San Peregrino Unidad de Investigacion, Aguascalientes

20817

RECRUITING

American Oncology Partners, P.A., Bethesda

21079

NOT_YET_RECRUITING

Centre Georges Francois Leclerc - service d'oncologie médicale, Dijon

21280

NOT_YET_RECRUITING

Dicle Universitesi Hastanesi, Diyarbakır

22030

NOT_YET_RECRUITING

Trakya Univ Hastanesi Ic Hastal, Edirne

25198

NOT_YET_RECRUITING

H.U Arnau De Vilanova Lleida, Lleida

27100

NOT_YET_RECRUITING

IRCCS Policlinico San Matteo, Università degli studi di Pavia, Pavia

28007

NOT_YET_RECRUITING

Hospital Beata Maria Ana, Madrid

28034

NOT_YET_RECRUITING

Hospital Universitario Ramon y Cajal - Oncología Médica, Madrid

28040

NOT_YET_RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

30120

NOT_YET_RECRUITING

Hospital Clínico Universitario Virgen De La Arrixaca, El Palmar

30727

NOT_YET_RECRUITING

Pratia MCM Kraków, Krakow

33200

NOT_YET_RECRUITING

VM Medical Park Mersin Hastanesi, Mersin

34214

NOT_YET_RECRUITING

Medipol Mega Hospital - Medical Oncology, Istanbul

34295

NOT_YET_RECRUITING

Medical Park Florya Hastanesi, Istanbul

34722

NOT_YET_RECRUITING

Goztepe SuleymanYalcin Sehir Hast, Istanbul

35575

NOT_YET_RECRUITING

Izmir Medical Park Hospital - Medical Oncology, Izmir

37126

NOT_YET_RECRUITING

Borgo Trento, Ospedale Civile Maggiore, AOU Integrata Verona, Verona

40225

NOT_YET_RECRUITING

Universitätsklinikum Düsseldorf - Gynecology, Düsseldorf

41000

NOT_YET_RECRUITING

Iaso Thessalia General Clinic Private Obstetrics S.A., Larissa

41001

NOT_YET_RECRUITING

Kocaeli Uni Uyg ve Ars Hst, İzmit

41110

NOT_YET_RECRUITING

General University Hospital Of Larissa, Larissa

41124

NOT_YET_RECRUITING

AOU di Modena, Policlinico di Modena - Attività Integrata di Oncologia ed Ematologia, Modena

42003

RECRUITING

Mercy Health-Paducah Cancer Center, Paducah

42080

NOT_YET_RECRUITING

Necmettin Erbakan University Meram Medical Faculty - Oncology, Konya

42283

NOT_YET_RECRUITING

Helios Klinikum Wuppertal, Wuppertal

43100

NOT_YET_RECRUITING

Ospedale Maggiore, AOU Parma, Parma

43210

NOT_YET_RECRUITING

Stefanie Spielman Comprehensive Breast Center at Olentangy River Road, Columbus

44033

RECRUITING

Ulsan University Hospital, Ulsan

44680

NOT_YET_RECRUITING

Office of Emanuel de la Mora Jimenez, MD/equiv, Guadalajara

44805

NOT_YET_RECRUITING

Centre de Lutte Contre le Cancer (CLCC) - Institut de Cancerologie de l'Ouest (ICO) - Rene Gauducheau - Oncology, Saint-Herblain

45060

NOT_YET_RECRUITING

SP ZOZ Opolskie Centrum Onkologii - Oddzial Onkologii Klinicznej z Odcinkiem Dziennym, Opole

46009

NOT_YET_RECRUITING

Fundacion Instituto Valenciano de Oncologia, Valencia

47014

NOT_YET_RECRUITING

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.R.L, Meldola

48202

NOT_YET_RECRUITING

Henry Ford Health System, Detroit

50603

NOT_YET_RECRUITING

Hospital Kuala Lumpur - Surgery, Kuala Lumpur

NOT_YET_RECRUITING

Pantai Hospital Kuala Lumpur, Kuala Lumpur

54639

NOT_YET_RECRUITING

Athens Medical Center S.A., Thessaloniki

NOT_YET_RECRUITING

Theageneio Cancer Hospital, Thessaloniki

55131

NOT_YET_RECRUITING

Universitätsmedizin Johannes Gutenberg, Mainz

57104

NOT_YET_RECRUITING

Sanford Health, Sioux Falls

58260

NOT_YET_RECRUITING

Administrative Society of Health Services, SC, Morelia

59102

NOT_YET_RECRUITING

SCL Health - Cancer Centers of Montana, Billings

62250

NOT_YET_RECRUITING

Institut Kanser Negara, Putrajaya

62500

NOT_YET_RECRUITING

Przychodnia Lekarska KOMED, Konin

63110

NOT_YET_RECRUITING

Washington University School of Medicine in Saint Louis, St Louis

NOT_YET_RECRUITING

Mays Cancer Center, San Antonio

64623

NOT_YET_RECRUITING

Avix Clinical Research, Monterrey

64710

NOT_YET_RECRUITING

Filios High Medicine, Monterrey

66113

NOT_YET_RECRUITING

CaritasKlinikum Saarbrücken St. Theresia, Saarbrücken

66205

NOT_YET_RECRUITING

The University of Kansas Cancer Center, Westwood

69495

NOT_YET_RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

71110

NOT_YET_RECRUITING

University General Hospital of Heraklion, Heraklion

71730

NOT_YET_RECRUITING

Zachodniopomorskie Centrum Onkologii - Osrodek Innowacyjnosci, Rozwoju i Badan Klinicznych, Szczecin

72015

NOT_YET_RECRUITING

Clinique Victor Hugo / Centre Jean Bernard, Le Mans

74120

NOT_YET_RECRUITING

Banphaeo General Hospital, Samut Sakhon

80054

NOT_YET_RECRUITING

Centre Hospitalier Universitaire D'Amiens (Hopital Sud) - Oncologie Medicale - Cancerolo, Amiens

80131

NOT_YET_RECRUITING

Istituto Nazionale dei Tumori - Fondazione Pascale, IRCCS, Napoli

85796

NOT_YET_RECRUITING

Centrum Onkologii im. prof. F. Lukaszczyka - Ambulatorium Chemioterapii, Bydgoszcz

86000

NOT_YET_RECRUITING

Centre Hospitalier Universitaire de Poitiers - Médico-Chirurgical De Cardiol, Poitiers

90110

NOT_YET_RECRUITING

Prince of Songkla University - Internal Medicine, Hat Yai

90302

NOT_YET_RECRUITING

Instytut Medyczny Santa Familia, Lodz

92835

NOT_YET_RECRUITING

Providence Medical Foundation, Fullerton

93003

NOT_YET_RECRUITING

UCLA Hematology Oncology Ventura, Los Angeles

93586

NOT_YET_RECRUITING

Hospital Umum Sarawak, Kuching

94800

NOT_YET_RECRUITING

Institut Gustave Roussy, Villejuif

100225

NOT_YET_RECRUITING

National Taiwan University Hospital - Oncology, Taipei

112201

NOT_YET_RECRUITING

Taipei Medical University - Shuang Ho Hospital Ministry of Health and Welfare - Nephrology, Taipei

NOT_YET_RECRUITING

Taipei Veterans General Hospital - Hematology, Taipei

200094

NOT_YET_RECRUITING

Onco Clinic Consult, Craiova

400015

NOT_YET_RECRUITING

Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti, Cluj-Napoca

404327

NOT_YET_RECRUITING

China Medical University Hospital - Breast Surgery, Taichung

407280

NOT_YET_RECRUITING

Radiotherapy Center Cluj, Floreşti

430295

NOT_YET_RECRUITING

Centrul de Oncologie Sf Nectarie - Medical Oncology, Baia Mare

NOT_YET_RECRUITING

Oncopremium Team - Medical Oncology, Baia Mare

500209

NOT_YET_RECRUITING

Changhua Christian Medical Foundation - Changhua Christian Hospital - Neurology, Changhua

700106

NOT_YET_RECRUITING

Centrul de Oncologie Euroclinic, Iași

700483

NOT_YET_RECRUITING

Institutul Regional de Oncologie Iasi - Medical Oncology, Iași

704302

NOT_YET_RECRUITING

National Cheng Kung University Hospital - Gynecology/Obstetrics, Tainan City

807377

NOT_YET_RECRUITING

Kaohsiung Medical University - Chung-Ho Memorial Hospital - Breast Surgery, Kaohsiung City

1998018

NOT_YET_RECRUITING

Hospital CUF Descobertas, Lisbon

64111-5965

NOT_YET_RECRUITING

Saint Luke's Cancer Institute, Kansas City

77030-4000

NOT_YET_RECRUITING

University of Texas MD Anderson Cancer Center, Houston

23114-3203

NOT_YET_RECRUITING

Bon Secours St. Francis Medical Oncology Center, Midlothian

B1884BBF

NOT_YET_RECRUITING

Centro de Oncologia e Investigacion Buenos Aires COIBA, Buenos Aires

B2700CPM

NOT_YET_RECRUITING

Pergamino Clinic, Buenos Aires

C1025ABI

NOT_YET_RECRUITING

CENIT Foundation, Buenos Aires

C1414

NOT_YET_RECRUITING

Fleischer Medical Center (Centro Medico Fleischer), Buenos Aires

C1426ABP

NOT_YET_RECRUITING

Fundacion Respirar, Buenos Aires

C1426AGE

NOT_YET_RECRUITING

Centro Oncológico Korben, Buenos Aires

C1426ANZ

NOT_YET_RECRUITING

Alexander Fleming Institute, Buenos Aires

Unknown

NOT_YET_RECRUITING

Center for Medical Education and Clinical Research (CEMIC), Buenos Aires

NOT_YET_RECRUITING

Centro Oncologico de Excelencia, La Plata

NOT_YET_RECRUITING

Fundación CORI, La Rioja

NOT_YET_RECRUITING

Rosario's Oncology Institute and Medical Specialities (IOR), Rosario

NOT_YET_RECRUITING

Istituto Clinico Humanitas, Milan

X5006HBF

NOT_YET_RECRUITING

Cordoba Oncology Institute (IONC), Córdoba

E3100HYB

NOT_YET_RECRUITING

Center of Nuclear and Molecular Medicine of Entre Rios (CEMENER), Paraná

66073-005

NOT_YET_RECRUITING

CTO Centro de Tratamento Oncológico, Belém

30360-680

NOT_YET_RECRUITING

Oncocentro Belo Horizonte, Belo Horizonte

60336-232

NOT_YET_RECRUITING

Centro Regional Integrado de Oncologia - CRIO, Fortaleza

60810-180

NOT_YET_RECRUITING

Pronutrir Oncologia e Nutrição, Fortaleza

98700-000

NOT_YET_RECRUITING

ONCOSITE - Centro de Pesquisa Clinica em Oncologia LTDA, Ijuí

88301-220

NOT_YET_RECRUITING

Catarina Pesquisa Clinica, Itajaí

90610-000

NOT_YET_RECRUITING

Hospital Sao Lucas da PUCRS, Porto Alegre

14051-140

NOT_YET_RECRUITING

Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP, Ribeirão Preto

40170-110

NOT_YET_RECRUITING

Bahia Oncology Center, Salvador

01509-010

NOT_YET_RECRUITING

Hospital A.C.Camargo, São Paulo

04543-000

NOT_YET_RECRUITING

Instituto D'or de Pesquisa e Ensino - ONCO STAR, São Paulo

656 53

NOT_YET_RECRUITING

Masarykuv onkologicky ustav - Oddeleni klinickych hodnoceni, Brno

268 31

NOT_YET_RECRUITING

Multiscan s.r.o. - Ambulance klinicke onkologie se stacionarem, Hořovice

500 05

NOT_YET_RECRUITING

FN Hradec Kralove - Klinika onkologie a radioterap, Hradec Králové

779 00

NOT_YET_RECRUITING

Fakultni nemocnice Olomouc - Onkologicka klinika, Olomouc

100 34

NOT_YET_RECRUITING

FN Kralovske Vinohrady - Radioterapeuticka a onkologicka klinika, Prague

140 59

NOT_YET_RECRUITING

Fakultni Thomayerova Nemocnice - Onkologicka klinika, Prague

150 06

NOT_YET_RECRUITING

Fakultni Nemocnice v Motole, Prague

14076 Cedex 05

NOT_YET_RECRUITING

Centre Georges François Baclesse, Caen

00128

NOT_YET_RECRUITING

Fondazione PU Campus Biomedico, Roma

00161

NOT_YET_RECRUITING

Umberto I Policlinico di Roma, Università La Sapienza, Roma

05100

NOT_YET_RECRUITING

Azienda Ospedaliera Santa Maria di Terni, Terni

NOT_YET_RECRUITING

"Ospedale Santa Maria delle Croci di Ravenna - Oncologia", Terni

04100

NOT_YET_RECRUITING

Clinical Research Center Chapultepec Mexico City, Mexico City

06760

NOT_YET_RECRUITING

Centro de Atencion Oncologica Viva, Mexico City

01748

NOT_YET_RECRUITING

LUX MED Onkologia Sp. z o.o., Szpital Szamocka - Oddzial Onkologii Klinicznej/Chemioterapii, Warsaw

02781

NOT_YET_RECRUITING

"Narodowy Instytut Onkologii im. Marii SkÅ'odowskiej-Curie †PaÅstwowy Instytut Badawczy - Klinika Nowotworow Piersi i Chirurg", Warsaw

3000-993

NOT_YET_RECRUITING

Centro Hospitalar e Universitário de Coimbra, Coimbra

1099-023

NOT_YET_RECRUITING

Instituto Portugues de Oncologia de Lisboa Francisco Gentil - Oncologia Medica, Lisbon

1500-650

NOT_YET_RECRUITING

Hospital da Luz de Lisboa - Learning Health, Lisbon

1649-035

NOT_YET_RECRUITING

H. de Santa Maria. Centro Hospitalar Lisboa Norte - Oncologia, Lisbon

4099-001

NOT_YET_RECRUITING

ULS de Santo Antonio E.P.E., Porto

022328

NOT_YET_RECRUITING

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Bucharest

02841

NOT_YET_RECRUITING

Korea University Anam Hospital - Gastroenterological Surgery, Seoul

03080

NOT_YET_RECRUITING

Seoul National University Hospital, Seoul

03722

NOT_YET_RECRUITING

Yonsei University Health System, Severance hospital, Seoul

05505

RECRUITING

Asan Medical Center - Oncology, Seoul

06273

NOT_YET_RECRUITING

Gangnam Severance Hospital, Seoul

06351

NOT_YET_RECRUITING

Samsung Medical Center - Hematology & Oncology, Seoul

08308

NOT_YET_RECRUITING

Korea University Guro Hospital, Seoul

06006

NOT_YET_RECRUITING

Hospital Universitario de Badajoz, Badajoz

08003

NOT_YET_RECRUITING

Hospital Del Mar, Barcelona

08036

NOT_YET_RECRUITING

Hospital Clinic De Barcelona, Barcelona

08908

NOT_YET_RECRUITING

Institut Catala D'oncologia, L'Hospitalet de Llobregat

01140

NOT_YET_RECRUITING

Medical Park Seyhan Hastanesi, Adana

06010

NOT_YET_RECRUITING

Gulhane Egitim Arastirma Hastanesi, Ankara

06100

NOT_YET_RECRUITING

Hacettepe University Medical Faculty - Hematology, Ankara

06200

NOT_YET_RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara

06520

NOT_YET_RECRUITING

Memorial Ankara Hastanesi, Ankara

06590

NOT_YET_RECRUITING

Ankara University Medical Faculty - Oncology, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celcuity Inc

INDUSTRY

NCT06757634 - Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2) | Biotech Hunter | Biotech Hunter